1k9j
From Proteopedia
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==Overview== | ==Overview== | ||
| - | Dendritic cell specific intracellular adhesion molecule-3 (ICAM-3) | + | Dendritic cell specific intracellular adhesion molecule-3 (ICAM-3) grabbing nonintegrin (DC-SIGN), a C-type lectin present on the surface of dendritic cells, mediates the initial interaction of dendritic cells with T cells by binding to ICAM-3. DC-SIGN and DC-SIGNR, a related receptor found on the endothelium of liver sinusoids, placental capillaries, and lymph nodes, bind to oligosaccharides that are present on the envelope of human immunodeficiency virus (HIV), an interaction that strongly promotes viral infection of T cells. Crystal structures of carbohydrate-recognition domains of DC-SIGN and of DC-SIGNR bound to oligosaccharide, in combination with binding studies, reveal that these receptors selectively recognize endogenous high-mannose oligosaccharides and may represent a new avenue for developing HIV prophylactics. |
==Disease== | ==Disease== | ||
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[[Category: Drickamer, K.]] | [[Category: Drickamer, K.]] | ||
[[Category: Feinberg, H.]] | [[Category: Feinberg, H.]] | ||
| - | [[Category: Mitchell, D | + | [[Category: Mitchell, D A.]] |
| - | [[Category: Weis, W | + | [[Category: Weis, W I.]] |
[[Category: CA]] | [[Category: CA]] | ||
[[Category: c-type lectin]] | [[Category: c-type lectin]] | ||
[[Category: protein carbohydrate complex]] | [[Category: protein carbohydrate complex]] | ||
| - | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on | + | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Feb 21 13:31:38 2008'' |
Revision as of 11:31, 21 February 2008
|
Complex of DC-SIGNR and GlcNAc2Man3
Contents |
Overview
Dendritic cell specific intracellular adhesion molecule-3 (ICAM-3) grabbing nonintegrin (DC-SIGN), a C-type lectin present on the surface of dendritic cells, mediates the initial interaction of dendritic cells with T cells by binding to ICAM-3. DC-SIGN and DC-SIGNR, a related receptor found on the endothelium of liver sinusoids, placental capillaries, and lymph nodes, bind to oligosaccharides that are present on the envelope of human immunodeficiency virus (HIV), an interaction that strongly promotes viral infection of T cells. Crystal structures of carbohydrate-recognition domains of DC-SIGN and of DC-SIGNR bound to oligosaccharide, in combination with binding studies, reveal that these receptors selectively recognize endogenous high-mannose oligosaccharides and may represent a new avenue for developing HIV prophylactics.
Disease
Known disease associated with this structure: SARS infection, protection against OMIM:[605872]
About this Structure
1K9J is a Single protein structure of sequence from Homo sapiens with as ligand. Full crystallographic information is available from OCA.
Reference
Structural basis for selective recognition of oligosaccharides by DC-SIGN and DC-SIGNR., Feinberg H, Mitchell DA, Drickamer K, Weis WI, Science. 2001 Dec 7;294(5549):2163-6. PMID:11739956
Page seeded by OCA on Thu Feb 21 13:31:38 2008
