1kbg
From Proteopedia
(New page: 200px<br /><applet load="1kbg" size="450" color="white" frame="true" align="right" spinBox="true" caption="1kbg, resolution 2.2Å" /> '''MHC CLASS I H-2KB PRE...) |
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| - | [[Image:1kbg.jpg|left|200px]]<br /><applet load="1kbg" size=" | + | [[Image:1kbg.jpg|left|200px]]<br /><applet load="1kbg" size="350" color="white" frame="true" align="right" spinBox="true" |
caption="1kbg, resolution 2.2Å" /> | caption="1kbg, resolution 2.2Å" /> | ||
'''MHC CLASS I H-2KB PRESENTED GLYCOPEPTIDE RGY8-6H-GAL2'''<br /> | '''MHC CLASS I H-2KB PRESENTED GLYCOPEPTIDE RGY8-6H-GAL2'''<br /> | ||
==Overview== | ==Overview== | ||
| - | T cell receptor (TCR) recognition of nonpeptidic and modified peptide | + | T cell receptor (TCR) recognition of nonpeptidic and modified peptide antigens has been recently uncovered but is still poorly understood. Immunization with an H-2Kb-restricted glycopeptide RGY8-6H-Gal2 generates a population of cytotoxic T cells that express both alpha/beta TCR, specific for glycopeptide, and gamma/delta TCR, specific for the disaccharide, even on glycolipids. The crystal structure of Kb/RGY8-6H-Gal2 now demonstrates that the peptide and H-2Kb structures are unaffected by the peptide glycosylation, but the central region of the putative TCR binding site is dominated by the extensive exposure of the tethered carbohydrate. These features of the Kb/RGY8-6H-Gal2 structure are consistent with the individual ligand binding preferences identified for the alpha/beta and gamma/delta TCRs and thus explain the generation of a carbohydrate-specific T cell response. |
==About this Structure== | ==About this Structure== | ||
| - | 1KBG is a [http://en.wikipedia.org/wiki/Protein_complex Protein complex] structure of sequences from [http://en.wikipedia.org/wiki/Mus_musculus Mus musculus] with NAG as [http://en.wikipedia.org/wiki/ligand ligand]. Full crystallographic information is available from [http:// | + | 1KBG is a [http://en.wikipedia.org/wiki/Protein_complex Protein complex] structure of sequences from [http://en.wikipedia.org/wiki/Mus_musculus Mus musculus] with <scene name='pdbligand=NAG:'>NAG</scene> as [http://en.wikipedia.org/wiki/ligand ligand]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1KBG OCA]. |
==Reference== | ==Reference== | ||
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[[Category: Mus musculus]] | [[Category: Mus musculus]] | ||
[[Category: Protein complex]] | [[Category: Protein complex]] | ||
| - | [[Category: Abdel-Motal, U | + | [[Category: Abdel-Motal, U M.]] |
[[Category: Jondal, M.]] | [[Category: Jondal, M.]] | ||
| - | [[Category: Speir, J | + | [[Category: Speir, J A.]] |
| - | [[Category: Wilson, I | + | [[Category: Wilson, I A.]] |
[[Category: NAG]] | [[Category: NAG]] | ||
[[Category: antigen presentation]] | [[Category: antigen presentation]] | ||
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[[Category: vaccine]] | [[Category: vaccine]] | ||
| - | ''Page seeded by [http:// | + | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Feb 21 13:32:11 2008'' |
Revision as of 11:32, 21 February 2008
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MHC CLASS I H-2KB PRESENTED GLYCOPEPTIDE RGY8-6H-GAL2
Overview
T cell receptor (TCR) recognition of nonpeptidic and modified peptide antigens has been recently uncovered but is still poorly understood. Immunization with an H-2Kb-restricted glycopeptide RGY8-6H-Gal2 generates a population of cytotoxic T cells that express both alpha/beta TCR, specific for glycopeptide, and gamma/delta TCR, specific for the disaccharide, even on glycolipids. The crystal structure of Kb/RGY8-6H-Gal2 now demonstrates that the peptide and H-2Kb structures are unaffected by the peptide glycosylation, but the central region of the putative TCR binding site is dominated by the extensive exposure of the tethered carbohydrate. These features of the Kb/RGY8-6H-Gal2 structure are consistent with the individual ligand binding preferences identified for the alpha/beta and gamma/delta TCRs and thus explain the generation of a carbohydrate-specific T cell response.
About this Structure
1KBG is a Protein complex structure of sequences from Mus musculus with as ligand. Full crystallographic information is available from OCA.
Reference
Crystal structure of an MHC class I presented glycopeptide that generates carbohydrate-specific CTL., Speir JA, Abdel-Motal UM, Jondal M, Wilson IA, Immunity. 1999 Jan;10(1):51-61. PMID:10023770
Page seeded by OCA on Thu Feb 21 13:32:11 2008
