1gq2
From Proteopedia
(New page: 200px<br /> <applet load="1gq2" size="450" color="white" frame="true" align="right" spinBox="true" caption="1gq2, resolution 2.5Å" /> '''MALIC ENZYME FROM PI...) |
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==About this Structure== | ==About this Structure== | ||
| - | 1GQ2 is a [[http://en.wikipedia.org/wiki/Single_protein Single protein]] structure of sequence from [[http://en.wikipedia.org/wiki/Columba_livia Columba livia]] with OXL, MN, CL, NA and NAP as [[http://en.wikipedia.org/wiki/ligands ligands]]. Active as [[http://en.wikipedia.org/wiki/ ]], with EC number [[http://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.1.1.40 1.1.1.40]]. Full crystallographic information is available from [[http://ispc.weizmann.ac.il/oca-bin/ocashort?id=1GQ2 OCA]]. | + | 1GQ2 is a [[http://en.wikipedia.org/wiki/Single_protein Single protein]] structure of sequence from [[http://en.wikipedia.org/wiki/Columba_livia Columba livia]] with OXL, MN, CL, NA and NAP as [[http://en.wikipedia.org/wiki/ligands ligands]]. Active as [[http://en.wikipedia.org/wiki/Malate_dehydrogenase_(oxaloacetate-decarboxylating)_(NADP(+)) Malate dehydrogenase (oxaloacetate-decarboxylating) (NADP(+))]], with EC number [[http://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.1.1.40 1.1.1.40]]. Structure known Active Site: 1. Full crystallographic information is available from [[http://ispc.weizmann.ac.il/oca-bin/ocashort?id=1GQ2 OCA]]. |
==Reference== | ==Reference== | ||
Structural studies of the pigeon cytosolic NADP(+)-dependent malic enzyme., Yang Z, Zhang H, Hung HC, Kuo CC, Tsai LC, Yuan HS, Chou WY, Chang GG, Tong L, Protein Sci. 2002 Feb;11(2):332-41. PMID:[http://ispc.weizmann.ac.il//pmbin/getpm?pmid=11790843 11790843] | Structural studies of the pigeon cytosolic NADP(+)-dependent malic enzyme., Yang Z, Zhang H, Hung HC, Kuo CC, Tsai LC, Yuan HS, Chou WY, Chang GG, Tong L, Protein Sci. 2002 Feb;11(2):332-41. PMID:[http://ispc.weizmann.ac.il//pmbin/getpm?pmid=11790843 11790843] | ||
[[Category: Columba livia]] | [[Category: Columba livia]] | ||
| + | [[Category: Malate dehydrogenase (oxaloacetate-decarboxylating) (NADP(+))]] | ||
[[Category: Single protein]] | [[Category: Single protein]] | ||
[[Category: Liang, T.]] | [[Category: Liang, T.]] | ||
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[[Category: pigeon liver]] | [[Category: pigeon liver]] | ||
| - | ''Page seeded by [http://ispc.weizmann.ac.il/oca OCA ] on | + | ''Page seeded by [http://ispc.weizmann.ac.il/oca OCA ] on Tue Oct 30 14:30:53 2007'' |
Revision as of 12:26, 30 October 2007
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MALIC ENZYME FROM PIGEON LIVER
Overview
Malic enzymes are widely distributed in nature, and have important, biological functions. They catalyze the oxidative decarboxylation of, malate to produce pyruvate and CO(2) in the presence of divalent cations, (Mg(2+), Mn(2+)). Most malic enzymes have a clear selectivity for the, dinucleotide cofactor, being able to use either NAD(+) or NADP(+), but not, both. Structural studies of the human mitochondrial NAD(+)-dependent malic, enzyme established that malic enzymes belong to a new class of oxidative, decarboxylases. Here we report the crystal structure of the pigeon, cytosolic NADP(+)-dependent malic enzyme, in a closed form, in a, quaternary complex with NADP(+), Mn(2+), and oxalate. This represents the, first structural information on an NADP(+)-dependent malic enzyme. Despite, the ... [(full description)]
About this Structure
1GQ2 is a [Single protein] structure of sequence from [Columba livia] with OXL, MN, CL, NA and NAP as [ligands]. Active as [Malate dehydrogenase (oxaloacetate-decarboxylating) (NADP(+))], with EC number [1.1.1.40]. Structure known Active Site: 1. Full crystallographic information is available from [OCA].
Reference
Structural studies of the pigeon cytosolic NADP(+)-dependent malic enzyme., Yang Z, Zhang H, Hung HC, Kuo CC, Tsai LC, Yuan HS, Chou WY, Chang GG, Tong L, Protein Sci. 2002 Feb;11(2):332-41. PMID:11790843
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