1gqw
From Proteopedia
(New page: 200px<br /> <applet load="1gqw" size="450" color="white" frame="true" align="right" spinBox="true" caption="1gqw, resolution 3.00Å" /> '''TAURINE/ALPHA-KETOG...) |
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==About this Structure== | ==About this Structure== | ||
| - | 1GQW is a [[http://en.wikipedia.org/wiki/Single_protein Single protein]] structure of sequence from [[http://en.wikipedia.org/wiki/Escherichia_coli Escherichia coli]] with FE2, TAU and AKG as [[http://en.wikipedia.org/wiki/ligands ligands]]. Active as [[http://en.wikipedia.org/wiki/ ]], with EC number [[http://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.14.11.17 1.14.11.17]]. Full crystallographic information is available from [[http://ispc.weizmann.ac.il/oca-bin/ocashort?id=1GQW OCA]]. | + | 1GQW is a [[http://en.wikipedia.org/wiki/Single_protein Single protein]] structure of sequence from [[http://en.wikipedia.org/wiki/Escherichia_coli Escherichia coli]] with FE2, TAU and AKG as [[http://en.wikipedia.org/wiki/ligands ligands]]. Active as [[http://en.wikipedia.org/wiki/Taurine_dioxygenase Taurine dioxygenase]], with EC number [[http://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.14.11.17 1.14.11.17]]. Structure known Active Site: FEA. Full crystallographic information is available from [[http://ispc.weizmann.ac.il/oca-bin/ocashort?id=1GQW OCA]]. |
==Reference== | ==Reference== | ||
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[[Category: Escherichia coli]] | [[Category: Escherichia coli]] | ||
[[Category: Single protein]] | [[Category: Single protein]] | ||
| + | [[Category: Taurine dioxygenase]] | ||
[[Category: Baldwin, J.E.]] | [[Category: Baldwin, J.E.]] | ||
[[Category: Burzlaff, N.I.]] | [[Category: Burzlaff, N.I.]] | ||
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[[Category: tfda]] | [[Category: tfda]] | ||
| - | ''Page seeded by [http://ispc.weizmann.ac.il/oca OCA ] on | + | ''Page seeded by [http://ispc.weizmann.ac.il/oca OCA ] on Tue Oct 30 14:31:05 2007'' |
Revision as of 12:26, 30 October 2007
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TAURINE/ALPHA-KETOGLUTARATE DIOXYGENASE FROM ESCHERICHIA COLI
Overview
Taurine/alpha-ketoglutarate dioxygenase (TauD), a non-heme Fe(II), oxygenase, catalyses the conversion of taurine (2-aminoethanesulfonate) to, sulfite and aminoacetaldehyde concurrent with the conversion of, alpha-ketoglutarate (alphaKG) to succinate and CO(2). The enzyme allows, Escherichia coli to use taurine, widely available in the environment, as, an alternative sulfur source. Here we describe the X-ray crystal structure, of TauD complexed to Fe(II) and both substrates, alphaKG and taurine. The, tertiary structure and fold of TauD are similar to those observed in other, enzymes from the broad family of Fe(II)/alphaKG-dependent oxygenases, with, closest structural similarity to clavaminate synthase. Using the TauD, coordinates, a model was determined for the closely related enzyme, ... [(full description)]
About this Structure
1GQW is a [Single protein] structure of sequence from [Escherichia coli] with FE2, TAU and AKG as [ligands]. Active as [Taurine dioxygenase], with EC number [1.14.11.17]. Structure known Active Site: FEA. Full crystallographic information is available from [OCA].
Reference
X-ray crystal structure of Escherichia coli taurine/alpha-ketoglutarate dioxygenase complexed to ferrous iron and substrates., Elkins JM, Ryle MJ, Clifton IJ, Dunning Hotopp JC, Lloyd JS, Burzlaff NI, Baldwin JE, Hausinger RP, Roach PL, Biochemistry. 2002 Apr 23;41(16):5185-92. PMID:11955067
Page seeded by OCA on Tue Oct 30 14:31:05 2007
Categories: Escherichia coli | Single protein | Taurine dioxygenase | Baldwin, J.E. | Burzlaff, N.I. | Clifton, I.J. | Dunning-Hotopp, J.C. | Elkins, J.M. | Hausinger, R.P. | Lloyd, J.S. | Roach, P.L. | Ryle, M.J. | AKG | FE2 | TAU | Alpha-ketoglutarate | Dioxygenase | Oxidoreductase | Oxygenase | Sulphur metabolism | Taud | Taurine | Tfda
