1gql
From Proteopedia
(New page: 200px<br /> <applet load="1gql" size="450" color="white" frame="true" align="right" spinBox="true" caption="1gql, resolution 1.67Å" /> '''STRUCTURE OF PSEUDO...) |
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==About this Structure== | ==About this Structure== | ||
| - | 1GQL is a [[http://en.wikipedia.org/wiki/Single_protein Single protein]] structure of sequence from [[http://en.wikipedia.org/wiki/ | + | 1GQL is a [[http://en.wikipedia.org/wiki/Single_protein Single protein]] structure of sequence from [[http://en.wikipedia.org/wiki/Cellvibrio_japonicus Cellvibrio japonicus]] with BDP, CO and EDO as [[http://en.wikipedia.org/wiki/ligands ligands]]. Active as [[http://en.wikipedia.org/wiki/Alpha-glucuronidase Alpha-glucuronidase]], with EC number [[http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.2.1.139 3.2.1.139]]. Structure known Active Site: AC1. Full crystallographic information is available from [[http://ispc.weizmann.ac.il/oca-bin/ocashort?id=1GQL OCA]]. |
==Reference== | ==Reference== | ||
The structural basis for catalysis and specificity of the Pseudomonas cellulosa alpha-glucuronidase, GlcA67A., Nurizzo D, Nagy T, Gilbert HJ, Davies GJ, Structure. 2002 Apr;10(4):547-56. PMID:[http://ispc.weizmann.ac.il//pmbin/getpm?pmid=11937059 11937059] | The structural basis for catalysis and specificity of the Pseudomonas cellulosa alpha-glucuronidase, GlcA67A., Nurizzo D, Nagy T, Gilbert HJ, Davies GJ, Structure. 2002 Apr;10(4):547-56. PMID:[http://ispc.weizmann.ac.il//pmbin/getpm?pmid=11937059 11937059] | ||
| - | [[Category: | + | [[Category: Alpha-glucuronidase]] |
| + | [[Category: Cellvibrio japonicus]] | ||
[[Category: Single protein]] | [[Category: Single protein]] | ||
[[Category: Davies, G.J.]] | [[Category: Davies, G.J.]] | ||
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[[Category: xylotriose]] | [[Category: xylotriose]] | ||
| - | ''Page seeded by [http://ispc.weizmann.ac.il/oca OCA ] on | + | ''Page seeded by [http://ispc.weizmann.ac.il/oca OCA ] on Tue Oct 30 14:31:09 2007'' |
Revision as of 12:26, 30 October 2007
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STRUCTURE OF PSEUDOMONAS CELLULOSA ALPHA-D-GLUCURONIDASE COMPLEXED WITH GLUCURONIC ACID AND XYLOTRIOSE
Overview
Alpha-glucuronidases, components of an ensemble of enzymes central to the, recycling of photosynthetic biomass, remove the alpha-1,2 linked, 4-O-methyl glucuronic acid from xylans. The structure of the, alpha-glucuronidase, GlcA67A, from Pseudomonas cellulosa reveals three, domains, the central of which is a (beta/alpha)(8) barrel housing the, catalytic apparatus. Complexes of the enzyme with the individual reaction, products, either xylobiose or glucuronic acid, and the ternary complex of, both glucuronic acid and xylotriose reveal a "blind" pocket which selects, for short decorated xylooligosaccharides substituted with the uronic acid, at their nonreducing end, consistent with kinetic data. The catalytic, center reveals a constellation of carboxylates; Glu292 is poised to, provide ... [(full description)]
About this Structure
1GQL is a [Single protein] structure of sequence from [Cellvibrio japonicus] with BDP, CO and EDO as [ligands]. Active as [Alpha-glucuronidase], with EC number [3.2.1.139]. Structure known Active Site: AC1. Full crystallographic information is available from [OCA].
Reference
The structural basis for catalysis and specificity of the Pseudomonas cellulosa alpha-glucuronidase, GlcA67A., Nurizzo D, Nagy T, Gilbert HJ, Davies GJ, Structure. 2002 Apr;10(4):547-56. PMID:11937059
Page seeded by OCA on Tue Oct 30 14:31:09 2007
