1kg0
From Proteopedia
(New page: 200px<br /> <applet load="1kg0" size="450" color="white" frame="true" align="right" spinBox="true" caption="1kg0, resolution 2.65Å" /> '''Structure of the Ep...) |
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| - | [[Image:1kg0.gif|left|200px]]<br /> | + | [[Image:1kg0.gif|left|200px]]<br /><applet load="1kg0" size="350" color="white" frame="true" align="right" spinBox="true" |
| - | <applet load="1kg0" size=" | + | |
caption="1kg0, resolution 2.65Å" /> | caption="1kg0, resolution 2.65Å" /> | ||
'''Structure of the Epstein-Barr Virus gp42 Protein Bound to the MHC class II Receptor HLA-DR1'''<br /> | '''Structure of the Epstein-Barr Virus gp42 Protein Bound to the MHC class II Receptor HLA-DR1'''<br /> | ||
==Overview== | ==Overview== | ||
| - | Epstein-Barr virus (EBV) causes infectious mononucleosis, establishes | + | Epstein-Barr virus (EBV) causes infectious mononucleosis, establishes long-term latent infections, and is associated with a variety of human tumors. The EBV gp42 glycoprotein binds MHC class II molecules, playing a critical role in infection of B lymphocytes. EBV gp42 belongs to the C-type lectin superfamily, with homology to NK receptors of the immune system. We report the crystal structure of gp42 bound to the human MHC class II molecule HLA-DR1. The gp42 binds HLA-DR1 using a surface site that is distinct from the canonical lectin and NK receptor ligand binding sites. At the canonical ligand binding site, gp42 forms a large hydrophobic groove, which could interact with other ligands necessary for EBV entry, providing a mechanism for coupling MHC recognition and membrane fusion. |
==About this Structure== | ==About this Structure== | ||
| - | 1KG0 is a [http://en.wikipedia.org/wiki/Protein_complex Protein complex] structure of sequences from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] and [http://en.wikipedia.org/wiki/Human_herpesvirus_4 Human herpesvirus 4]. Full crystallographic information is available from [http:// | + | 1KG0 is a [http://en.wikipedia.org/wiki/Protein_complex Protein complex] structure of sequences from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] and [http://en.wikipedia.org/wiki/Human_herpesvirus_4 Human herpesvirus 4]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1KG0 OCA]. |
==Reference== | ==Reference== | ||
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[[Category: Human herpesvirus 4]] | [[Category: Human herpesvirus 4]] | ||
[[Category: Protein complex]] | [[Category: Protein complex]] | ||
| - | [[Category: Haan, K | + | [[Category: Haan, K M.]] |
| - | [[Category: Jardetzky, T | + | [[Category: Jardetzky, T S.]] |
[[Category: Longnecker, R.]] | [[Category: Longnecker, R.]] | ||
| - | [[Category: Mullen, M | + | [[Category: Mullen, M M.]] |
[[Category: c-type lectin domain]] | [[Category: c-type lectin domain]] | ||
[[Category: membrane fusion]] | [[Category: membrane fusion]] | ||
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[[Category: virus]] | [[Category: virus]] | ||
| - | ''Page seeded by [http:// | + | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Feb 21 13:33:44 2008'' |
Revision as of 11:33, 21 February 2008
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Structure of the Epstein-Barr Virus gp42 Protein Bound to the MHC class II Receptor HLA-DR1
Overview
Epstein-Barr virus (EBV) causes infectious mononucleosis, establishes long-term latent infections, and is associated with a variety of human tumors. The EBV gp42 glycoprotein binds MHC class II molecules, playing a critical role in infection of B lymphocytes. EBV gp42 belongs to the C-type lectin superfamily, with homology to NK receptors of the immune system. We report the crystal structure of gp42 bound to the human MHC class II molecule HLA-DR1. The gp42 binds HLA-DR1 using a surface site that is distinct from the canonical lectin and NK receptor ligand binding sites. At the canonical ligand binding site, gp42 forms a large hydrophobic groove, which could interact with other ligands necessary for EBV entry, providing a mechanism for coupling MHC recognition and membrane fusion.
About this Structure
1KG0 is a Protein complex structure of sequences from Homo sapiens and Human herpesvirus 4. Full crystallographic information is available from OCA.
Reference
Structure of the Epstein-Barr virus gp42 protein bound to the MHC class II receptor HLA-DR1., Mullen MM, Haan KM, Longnecker R, Jardetzky TS, Mol Cell. 2002 Feb;9(2):375-85. PMID:11864610
Page seeded by OCA on Thu Feb 21 13:33:44 2008
