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Group:MUZIC:Mena VASP
From Proteopedia
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== Function and interaction == | == Function and interaction == | ||
| - | EVH1 domain of Mena/VASP binds to the cytoskeleton proteins containing FPPPP motif, such as vinculin <ref>PMID:8980130</ref>, lamellipodin <ref>PMID:15469845</ref>, zyxin <ref>PMID:10801818</ref>, palladin <ref>PMID:14983521</ref> and Xin <ref>PMID:16631741</ref>. The Pro-rich region of Mena/VASP binds profilin and the SH3 and WW domains of various signaling and scaffolding proteins. EVH2 domain comprises F- ang G-Actin binding sites and C-terminal coiled coil region, also known as tetramerization domain <ref>PMID:10438535</ref>. It was shown recently that Mena binds with fibronectin receptor α5β1 integrin via “LERER" motif <ref>PMID:22908313</ref>. It is suggested that Mena/VASP bind to the barbed end of actin filaments and prevent their capping by CapZ <ref>PMID:10438535</ref>. Regulation of VASP protein activity occurs through phosphorylation at Ser-157, Ser-239, and Thr-278 by cAMP and cGMP induced protein kinases (PCA/PCG) by unknown mechanisms. Whereas the first two phosphorylation sites are conserved in Mena, EVL contains only the first site <ref>PMID:19825941</ref>. | + | EVH1 domain of Mena/VASP binds to the cytoskeleton proteins containing FPPPP motif, such as vinculin <ref>PMID:8980130</ref>, lamellipodin <ref>PMID:15469845</ref>, zyxin <ref>PMID:10801818</ref>, palladin <ref>PMID:14983521</ref> and Xin <ref>PMID:16631741</ref>. The Pro-rich region of Mena/VASP binds profilin and the SH3 and WW domains of various signaling and scaffolding proteins. EVH2 domain comprises F- ang G-Actin binding sites and C-terminal coiled coil region, also known as tetramerization domain <ref>PMID:10438535</ref>. It was shown recently that Mena binds with fibronectin receptor α5β1 integrin via “LERER" motif <ref>PMID:22908313</ref>. It is suggested that Mena/VASP bind to the barbed end of actin filaments and prevent their capping by CapZ <ref>PMID:10438535</ref>. Regulation of VASP protein activity occurs through phosphorylation at Ser-157, Ser-239, and Thr-278 by cAMP and cGMP induced protein kinases (PCA/PCG) by unknown mechanisms. Whereas the first two phosphorylation sites are conserved in Mena, EVL contains only the first site <ref>PMID:19825941</ref>,<ref>PMID:17082196</ref>. |
Revision as of 20:32, 3 October 2012
Mena/VASP
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