1koe
From Proteopedia
(New page: 200px<br /><applet load="1koe" size="450" color="white" frame="true" align="right" spinBox="true" caption="1koe, resolution 1.50Å" /> '''ENDOSTATIN'''<br /> ...) |
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| - | [[Image:1koe.gif|left|200px]]<br /><applet load="1koe" size=" | + | [[Image:1koe.gif|left|200px]]<br /><applet load="1koe" size="350" color="white" frame="true" align="right" spinBox="true" |
caption="1koe, resolution 1.50Å" /> | caption="1koe, resolution 1.50Å" /> | ||
'''ENDOSTATIN'''<br /> | '''ENDOSTATIN'''<br /> | ||
==Overview== | ==Overview== | ||
| - | A number of extracellular proteins contain cryptic inhibitors of | + | A number of extracellular proteins contain cryptic inhibitors of angiogenesis. Endostatin is a 20 kDa C-terminal proteolytic fragment of collagen XVIII that potently inhibits endothelial cell proliferation and angiogenesis. Therapy of experimental cancer with endostatin leads to tumour dormancy and does not induce resistance. We have expressed recombinant mouse endostatin and determined its crystal structure at 1.5 A resolution. The structure reveals a compact fold distantly related to the C-type lectin carbohydrate recognition domain and the hyaluronan-binding Link module. The high affinity of endostatin for heparin is explained by the presence of an extensive basic patch formed by 11 arginine residues. Endostatin may inhibit angiogenesis by binding to the heparan sulphate proteoglycans involved in growth factor signalling. |
==About this Structure== | ==About this Structure== | ||
| - | 1KOE is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http:// | + | 1KOE is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1KOE OCA]. |
==Reference== | ==Reference== | ||
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[[Category: Single protein]] | [[Category: Single protein]] | ||
[[Category: Hohenester, E.]] | [[Category: Hohenester, E.]] | ||
| - | [[Category: Olsen, B | + | [[Category: Olsen, B R.]] |
[[Category: Sasaki, T.]] | [[Category: Sasaki, T.]] | ||
[[Category: Timpl, R.]] | [[Category: Timpl, R.]] | ||
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[[Category: non-collageneous domain]] | [[Category: non-collageneous domain]] | ||
| - | ''Page seeded by [http:// | + | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Feb 21 13:36:18 2008'' |
Revision as of 11:36, 21 February 2008
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ENDOSTATIN
Overview
A number of extracellular proteins contain cryptic inhibitors of angiogenesis. Endostatin is a 20 kDa C-terminal proteolytic fragment of collagen XVIII that potently inhibits endothelial cell proliferation and angiogenesis. Therapy of experimental cancer with endostatin leads to tumour dormancy and does not induce resistance. We have expressed recombinant mouse endostatin and determined its crystal structure at 1.5 A resolution. The structure reveals a compact fold distantly related to the C-type lectin carbohydrate recognition domain and the hyaluronan-binding Link module. The high affinity of endostatin for heparin is explained by the presence of an extensive basic patch formed by 11 arginine residues. Endostatin may inhibit angiogenesis by binding to the heparan sulphate proteoglycans involved in growth factor signalling.
About this Structure
1KOE is a Single protein structure of sequence from Mus musculus. Full crystallographic information is available from OCA.
Reference
Crystal structure of the angiogenesis inhibitor endostatin at 1.5 A resolution., Hohenester E, Sasaki T, Olsen BR, Timpl R, EMBO J. 1998 Mar 16;17(6):1656-64. PMID:9501087
Page seeded by OCA on Thu Feb 21 13:36:18 2008
