Retinoid X receptor (RXR) is a nuclear receptor activated by 9-cis retinoic acid. RXR makes a heterodimer with subfamily 1 nuclear receptors including retinoic acid receptor (RAR). In the absence of ligand, the RAR/RXR complex binds the hormone response elements complexed with corepressor protein. Upon binding of the ligand, the corepressor disassociates from the receptor and associates with the coactivator leading to transcription activation. RAR contains a DNA-binding domain (DBD) and ligand-binding domain (LBD). There are 3 classes of RXR: α, β and γ.
3D structures of retinoid X receptor
Retinoid X receptor α
3nsp, 1lbd, 1g1u - hRXR LBD – human
1rxr – hRXR DBD (mutant) – NMR
1by4 – hRXR + DNA
1g5y - hRXR LBD + retinoid
1dkf – mRXR LBD + mRAR LBD – mouse
1dsz - hRXR LBD + hRAR LBD + DNA
1fby - hRXR LBD + 9-cis retinoic acid
3nsq - hRXR LBD + antagonist
3a9e - hRXR LBD + hRAR LBD + coactivator peptide
3fug - hRXR LBD + coactivator peptide
3fc6 – hRXR LBD + NR1H3 protein
3r29 - hRXR LBD + corepressor peptide SMRT2
3r2a - hRXR LBD + corepressor peptide SMRT2 + antagonist
3h0a, 1fm6, 1fm9, 1k74 - hRXR LBD + PPAR-γ + 9-cis retinoic acid + coactivator peptide
1rdt - hRXR LBD + PPAR-γ + coactivator peptide
3dzu, 3dzy, 3e00 - hRXR LBD + PPAR-γ + 9-cis retinoic acid + coactivator peptide + DNA
3oap - hRXR LBD + 9-cis retinoic acid + coactivator peptide
3uvv - hRXR LBD + 9-cis retinoic acid + thyronine + thyroid hormone receptor α
3ozj - hRXR LBD + bigelovin + coactivator peptide
3pcu - hRXR LBD + rutamarin + coactivator peptide
2zxz, 2zy0, 3r5m, 1mzn, 1mv9, 1mvc - hRXR LBD + agonist + coactivator peptide
2acl - hRXR LBD + agonist + oxysterols receptor α
3fal - hRXR LBD + modulator + oxysterols receptor α + 9-cis retinoic acid
3kwy - hRXR LBD + triphenyltin + coactivator peptide
3e94 - hRXR LBD + tributylin + coactivator peptide
2p1t, 2p1u, 2p1v - hRXR LBD + retinoid + coactivator peptide
1xls - hRXR LBD (mutant) + orphan nuclear receptor NR1I3 + coactivator peptide
1xv9 - hRXR LBD + orphan nuclear receptor NR1I3 + pregnane + coactivator peptide
1xvp - hRXR LBD + orphan nuclear receptor NR1I3 + CITCO + coactivator peptide
Retinoid X receptor β
1xdk - mRXR LBD + mRAR LBD + thyroid receptor associated protein
1uhl - hRXR LBD + oxysterols receptor α + coactivator peptide
1h9u – hRXR LBD + agonist
Retinoid X receptor γ
2gl8 – hRXR LBD
