1kq9
From Proteopedia
(New page: 200px<br /> <applet load="1kq9" size="450" color="white" frame="true" align="right" spinBox="true" caption="1kq9, resolution 1.90Å" /> '''Human methionine am...) |
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| - | [[Image:1kq9.gif|left|200px]]<br /> | + | [[Image:1kq9.gif|left|200px]]<br /><applet load="1kq9" size="350" color="white" frame="true" align="right" spinBox="true" |
| - | <applet load="1kq9" size=" | + | |
caption="1kq9, resolution 1.90Å" /> | caption="1kq9, resolution 1.90Å" /> | ||
'''Human methionine aminopeptidase type II in complex with L-methionine'''<br /> | '''Human methionine aminopeptidase type II in complex with L-methionine'''<br /> | ||
==Overview== | ==Overview== | ||
| - | Human methionine aminopeptidase type 2 (hMetAP-2) was identified as the | + | Human methionine aminopeptidase type 2 (hMetAP-2) was identified as the molecular target of anti-angiogenic agents such as fumagillin and its analogues. We describe here the crystal structure of hMetAP-2 in complex with l-methionine and d-methionine at 1.9 and 2.0A resolution, respectively. The comparison of the structure of the two complexes establishes the basis of enantiomer discrimination and provides some considerations for the design of selective MetAP-2 inhibitors. |
==About this Structure== | ==About this Structure== | ||
| - | 1KQ9 is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] with ZN, MET and TBU as [http://en.wikipedia.org/wiki/ligands ligands]. Active as [http://en.wikipedia.org/wiki/Methionyl_aminopeptidase Methionyl aminopeptidase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.4.11.18 3.4.11.18] Full crystallographic information is available from [http:// | + | 1KQ9 is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] with <scene name='pdbligand=ZN:'>ZN</scene>, <scene name='pdbligand=MET:'>MET</scene> and <scene name='pdbligand=TBU:'>TBU</scene> as [http://en.wikipedia.org/wiki/ligands ligands]. Active as [http://en.wikipedia.org/wiki/Methionyl_aminopeptidase Methionyl aminopeptidase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.4.11.18 3.4.11.18] Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1KQ9 OCA]. |
==Reference== | ==Reference== | ||
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[[Category: Single protein]] | [[Category: Single protein]] | ||
[[Category: Clardy, J.]] | [[Category: Clardy, J.]] | ||
| - | [[Category: Nonato, M | + | [[Category: Nonato, M C.]] |
[[Category: Widom, J.]] | [[Category: Widom, J.]] | ||
[[Category: MET]] | [[Category: MET]] | ||
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[[Category: central b-sheet and two pairs of a-helices]] | [[Category: central b-sheet and two pairs of a-helices]] | ||
| - | ''Page seeded by [http:// | + | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Feb 21 13:36:46 2008'' |
Revision as of 11:36, 21 February 2008
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Human methionine aminopeptidase type II in complex with L-methionine
Overview
Human methionine aminopeptidase type 2 (hMetAP-2) was identified as the molecular target of anti-angiogenic agents such as fumagillin and its analogues. We describe here the crystal structure of hMetAP-2 in complex with l-methionine and d-methionine at 1.9 and 2.0A resolution, respectively. The comparison of the structure of the two complexes establishes the basis of enantiomer discrimination and provides some considerations for the design of selective MetAP-2 inhibitors.
About this Structure
1KQ9 is a Single protein structure of sequence from Homo sapiens with , and as ligands. Active as Methionyl aminopeptidase, with EC number 3.4.11.18 Full crystallographic information is available from OCA.
Reference
Human methionine aminopeptidase type 2 in complex with L- and D-methionine., Nonato MC, Widom J, Clardy J, Bioorg Med Chem Lett. 2006 May 15;16(10):2580-3. Epub 2006 Mar 15. PMID:16540317
Page seeded by OCA on Thu Feb 21 13:36:46 2008
