1kqf

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(New page: 200px<br /><applet load="1kqf" size="450" color="white" frame="true" align="right" spinBox="true" caption="1kqf, resolution 1.60&Aring;" /> '''FORMATE DEHYDROGENAS...)
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[[Image:1kqf.gif|left|200px]]<br /><applet load="1kqf" size="350" color="white" frame="true" align="right" spinBox="true"
caption="1kqf, resolution 1.60&Aring;" />
caption="1kqf, resolution 1.60&Aring;" />
'''FORMATE DEHYDROGENASE N FROM E. COLI'''<br />
'''FORMATE DEHYDROGENASE N FROM E. COLI'''<br />
==Overview==
==Overview==
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The structure of the membrane protein formate dehydrogenase-N (Fdn-N), a, major component of Escherichia coli nitrate respiration, has been, determined at 1.6 angstroms. The structure demonstrates 11 redox centers, including molybdopterin-guanine dinucleotides, five [4Fe-4S] clusters, two, heme b groups, and a menaquinone analog. These redox centers are aligned, in a single chain, which extends almost 90 angstroms through the enzyme., The menaquinone reduction site associated with a possible proton pathway, was also characterized. This structure provides critical insights into the, proton motive force generation by redox loop, a common mechanism among a, wide range of respiratory enzymes.
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The structure of the membrane protein formate dehydrogenase-N (Fdn-N), a major component of Escherichia coli nitrate respiration, has been determined at 1.6 angstroms. The structure demonstrates 11 redox centers, including molybdopterin-guanine dinucleotides, five [4Fe-4S] clusters, two heme b groups, and a menaquinone analog. These redox centers are aligned in a single chain, which extends almost 90 angstroms through the enzyme. The menaquinone reduction site associated with a possible proton pathway was also characterized. This structure provides critical insights into the proton motive force generation by redox loop, a common mechanism among a wide range of respiratory enzymes.
==About this Structure==
==About this Structure==
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1KQF is a [http://en.wikipedia.org/wiki/Protein_complex Protein complex] structure of sequences from [http://en.wikipedia.org/wiki/Escherichia_coli Escherichia coli] with 6MO, SF4, MGD, HEM and CDL as [http://en.wikipedia.org/wiki/ligands ligands]. Active as [http://en.wikipedia.org/wiki/Formate_dehydrogenase Formate dehydrogenase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.2.1.2 1.2.1.2] Full crystallographic information is available from [http://ispc.weizmann.ac.il/oca-bin/ocashort?id=1KQF OCA].
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1KQF is a [http://en.wikipedia.org/wiki/Protein_complex Protein complex] structure of sequences from [http://en.wikipedia.org/wiki/Escherichia_coli Escherichia coli] with <scene name='pdbligand=6MO:'>6MO</scene>, <scene name='pdbligand=SF4:'>SF4</scene>, <scene name='pdbligand=MGD:'>MGD</scene>, <scene name='pdbligand=HEM:'>HEM</scene> and <scene name='pdbligand=CDL:'>CDL</scene> as [http://en.wikipedia.org/wiki/ligands ligands]. Active as [http://en.wikipedia.org/wiki/Formate_dehydrogenase Formate dehydrogenase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.2.1.2 1.2.1.2] Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1KQF OCA].
==Reference==
==Reference==
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[[Category: selenocysteine]]
[[Category: selenocysteine]]
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''Page seeded by [http://ispc.weizmann.ac.il/oca OCA ] on Tue Nov 20 19:38:53 2007''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Feb 21 13:36:50 2008''

Revision as of 11:36, 21 February 2008

Image:1kqf.gif

1kqf, resolution 1.60Å

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FORMATE DEHYDROGENASE N FROM E. COLI

Overview

The structure of the membrane protein formate dehydrogenase-N (Fdn-N), a major component of Escherichia coli nitrate respiration, has been determined at 1.6 angstroms. The structure demonstrates 11 redox centers, including molybdopterin-guanine dinucleotides, five [4Fe-4S] clusters, two heme b groups, and a menaquinone analog. These redox centers are aligned in a single chain, which extends almost 90 angstroms through the enzyme. The menaquinone reduction site associated with a possible proton pathway was also characterized. This structure provides critical insights into the proton motive force generation by redox loop, a common mechanism among a wide range of respiratory enzymes.

About this Structure

1KQF is a Protein complex structure of sequences from Escherichia coli with , , , and as ligands. Active as Formate dehydrogenase, with EC number 1.2.1.2 Full crystallographic information is available from OCA.

Reference

Molecular basis of proton motive force generation: structure of formate dehydrogenase-N., Jormakka M, Tornroth S, Byrne B, Iwata S, Science. 2002 Mar 8;295(5561):1863-8. PMID:11884747

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