1ktj
From Proteopedia
(New page: 200px<br /><applet load="1ktj" size="450" color="white" frame="true" align="right" spinBox="true" caption="1ktj, resolution 2.15Å" /> '''X-ray Structure Of D...) |
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| - | [[Image:1ktj.gif|left|200px]]<br /><applet load="1ktj" size=" | + | [[Image:1ktj.gif|left|200px]]<br /><applet load="1ktj" size="350" color="white" frame="true" align="right" spinBox="true" |
caption="1ktj, resolution 2.15Å" /> | caption="1ktj, resolution 2.15Å" /> | ||
'''X-ray Structure Of Der P 2, The Major House Dust Mite Allergen'''<br /> | '''X-ray Structure Of Der P 2, The Major House Dust Mite Allergen'''<br /> | ||
==Overview== | ==Overview== | ||
| - | The crystal structure of the common house mite (Dermatophagoides sp.) Der | + | The crystal structure of the common house mite (Dermatophagoides sp.) Der p 2 allergen was solved at 2.15 A resolution using the MAD phasing technique, and refined to an R-factor of 0.209. The refined atomic model, which reveals an immunoglobulin-like tertiary fold, differs in important ways from the previously described NMR structure, because the two beta-sheets are significantly further apart and create an internal cavity, which is occupied by a hydrophobic ligand. This interaction is structurally reminiscent of the binding of a prenyl group by a regulatory protein, the Rho guanine nucleotide exchange inhibitor. The crystal structure suggests that binding of non-polar molecules may be essential to the physiological function of the Der p 2 protein. |
==About this Structure== | ==About this Structure== | ||
| - | 1KTJ is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Dermatophagoides_pteronyssinus Dermatophagoides pteronyssinus]. Full crystallographic information is available from [http:// | + | 1KTJ is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Dermatophagoides_pteronyssinus Dermatophagoides pteronyssinus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1KTJ OCA]. |
==Reference== | ==Reference== | ||
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[[Category: Dermatophagoides pteronyssinus]] | [[Category: Dermatophagoides pteronyssinus]] | ||
[[Category: Single protein]] | [[Category: Single protein]] | ||
| - | [[Category: Benjamin, D | + | [[Category: Benjamin, D C.]] |
[[Category: Dauter, Z.]] | [[Category: Dauter, Z.]] | ||
[[Category: Derewenda, U.]] | [[Category: Derewenda, U.]] | ||
[[Category: Derewenda, Z.]] | [[Category: Derewenda, Z.]] | ||
[[Category: Li, J.]] | [[Category: Li, J.]] | ||
| - | [[Category: Mueller, G | + | [[Category: Mueller, G A.]] |
| - | [[Category: Rule, G | + | [[Category: Rule, G S.]] |
[[Category: allergen]] | [[Category: allergen]] | ||
[[Category: asthma]] | [[Category: asthma]] | ||
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[[Category: x-ray structure]] | [[Category: x-ray structure]] | ||
| - | ''Page seeded by [http:// | + | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Feb 21 13:37:47 2008'' |
Revision as of 11:37, 21 February 2008
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X-ray Structure Of Der P 2, The Major House Dust Mite Allergen
Overview
The crystal structure of the common house mite (Dermatophagoides sp.) Der p 2 allergen was solved at 2.15 A resolution using the MAD phasing technique, and refined to an R-factor of 0.209. The refined atomic model, which reveals an immunoglobulin-like tertiary fold, differs in important ways from the previously described NMR structure, because the two beta-sheets are significantly further apart and create an internal cavity, which is occupied by a hydrophobic ligand. This interaction is structurally reminiscent of the binding of a prenyl group by a regulatory protein, the Rho guanine nucleotide exchange inhibitor. The crystal structure suggests that binding of non-polar molecules may be essential to the physiological function of the Der p 2 protein.
About this Structure
1KTJ is a Single protein structure of sequence from Dermatophagoides pteronyssinus. Full crystallographic information is available from OCA.
Reference
The crystal structure of a major dust mite allergen Der p 2, and its biological implications., Derewenda U, Li J, Derewenda Z, Dauter Z, Mueller GA, Rule GS, Benjamin DC, J Mol Biol. 2002 Apr 19;318(1):189-97. PMID:12054778
Page seeded by OCA on Thu Feb 21 13:37:47 2008
