1kw4
From Proteopedia
(New page: 200px<br /><applet load="1kw4" size="450" color="white" frame="true" align="right" spinBox="true" caption="1kw4, resolution 1.75Å" /> '''Polyhomeotic SAM dom...) |
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| - | [[Image:1kw4.jpg|left|200px]]<br /><applet load="1kw4" size=" | + | [[Image:1kw4.jpg|left|200px]]<br /><applet load="1kw4" size="350" color="white" frame="true" align="right" spinBox="true" |
caption="1kw4, resolution 1.75Å" /> | caption="1kw4, resolution 1.75Å" /> | ||
'''Polyhomeotic SAM domain structure'''<br /> | '''Polyhomeotic SAM domain structure'''<br /> | ||
==Overview== | ==Overview== | ||
| - | The polycomb group (PcG) proteins are important in the maintenance of | + | The polycomb group (PcG) proteins are important in the maintenance of stable repression patterns during development. Several PcG members contain a protein protein interaction module called a SAM domain (also known as SPM, PNT and HLH). Here we report the high-resolution structure of the SAM domain of polyhomeotic (Ph). Ph-SAM forms a helical polymer structure, providing a likely mechanism for the extension of PcG complexes. The structure of the polymer resembles that formed by the SAM domain of another transcriptional repressor, TEL. The formation of these polymer structures by SAM domains in two divergent repressors suggests a conserved mode of repression involving a higher order chromatin structure. |
==About this Structure== | ==About this Structure== | ||
| - | 1KW4 is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Drosophila_melanogaster Drosophila melanogaster]. Full crystallographic information is available from [http:// | + | 1KW4 is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Drosophila_melanogaster Drosophila melanogaster]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1KW4 OCA]. |
==Reference== | ==Reference== | ||
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[[Category: Drosophila melanogaster]] | [[Category: Drosophila melanogaster]] | ||
[[Category: Single protein]] | [[Category: Single protein]] | ||
| - | [[Category: Bowie, J | + | [[Category: Bowie, J U.]] |
[[Category: Gingery, M.]] | [[Category: Gingery, M.]] | ||
| - | [[Category: Kim, C | + | [[Category: Kim, C A.]] |
| - | [[Category: Pilpa, R | + | [[Category: Pilpa, R M.]] |
[[Category: polycomb group]] | [[Category: polycomb group]] | ||
[[Category: polymer]] | [[Category: polymer]] | ||
[[Category: sam domain]] | [[Category: sam domain]] | ||
| - | ''Page seeded by [http:// | + | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Feb 21 13:38:35 2008'' |
Revision as of 11:38, 21 February 2008
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Polyhomeotic SAM domain structure
Overview
The polycomb group (PcG) proteins are important in the maintenance of stable repression patterns during development. Several PcG members contain a protein protein interaction module called a SAM domain (also known as SPM, PNT and HLH). Here we report the high-resolution structure of the SAM domain of polyhomeotic (Ph). Ph-SAM forms a helical polymer structure, providing a likely mechanism for the extension of PcG complexes. The structure of the polymer resembles that formed by the SAM domain of another transcriptional repressor, TEL. The formation of these polymer structures by SAM domains in two divergent repressors suggests a conserved mode of repression involving a higher order chromatin structure.
About this Structure
1KW4 is a Single protein structure of sequence from Drosophila melanogaster. Full crystallographic information is available from OCA.
Reference
The SAM domain of polyhomeotic forms a helical polymer., Kim CA, Gingery M, Pilpa RM, Bowie JU, Nat Struct Biol. 2002 Jun;9(6):453-7. PMID:11992127
Page seeded by OCA on Thu Feb 21 13:38:35 2008
