Integrins (IG) are receptors which mediate the attachment between cells or to extracellular matrix. They are involved in cellular signaling and cell cycle. IGs contain alpha and beta chain. IG subunits span the cell membrane. Both subunits bind divalent cations some of which bind the ligands which interact with IG. Some IGs contain an insertion domain named I domain.
3D structures of integrin
IG CR3
1ido – hIG I domain + Mg – human
1jlm - hIG I domain + Mn
IG CD11a
1lfa - hIG I domain + Mn
1zon - hIG I domain
1zoo, 1zop, 3f74 - hIG I domain + Mg
1mq9 - hIG I domain (mutant) + Mn
1mjn - hIG I domain (mutant) + Mg
1mqa - hIG I domain (mutant)
2k8o – hIG cytoplasmic domain (mutant) – NMR
IG CD11a complexes
1cqp - hIG I domain + lovastatin + Mg
1mq8, 3bn3, 3tcx - hIG I domain (mutant) + intracellular adhesion molecule + Mg
1t0p - hIG I domain + intracellular adhesion molecule-3 + Mg
1rd4, 2ica, 3bqm, 3bqn, 3e2m - hIG I domain + inhibitor
2o7n, 3m6f - hIG I domain + antagonist
1xdd, 1xdg, 1xuo - hIG I domain + inhibitor + Mg
3f78 - hIG I domain + anesthetic + Mg
3eoa, 3eob - hIG I domain + antibody
3hi6 - hIG I domain (mutant) + antibody + Mn
IG CD11b
1bho - hIG I domain + Mg
1bhq - hIG I domain + Cd
1m1u - hIG I domain (mutant) + Ca
1n9z - hIG I domain (mutant) + Mg
1idn, 1na5 - hIG I domain
1mf7 - hIG I domain (mutant)
IG CD11c
1n3y - hIG I domain (mutant)
IG α-1
1ck4 - rIG I domain – rat
4a0q - hIG I domain (mutant) + Mg
2l8s - hIG transmembrane domain – NMR
1mhp - rIG I domain (mutant) + antibody + Mn
IG α-2
1dzi - hIG I domain + collagen peptide
1v7p - hIG I domain (mutant) + EMS16 + Mn
IG α-2b
2k1a - hIG transmembrane domain – NMR
IG α-M
2lke, [[2lkj – hIG cytoplasmic domain – NMR
IG α-X
2luv – hIG cytoplasmic domain – NMR
IG α-1 β-1
1qc5, 1qcy - hIG I domain (mutant) + Mg
1pt6 - hIG I domain + Mg
IG α-2 β
1aox - hIG I domain (mutant) + Mg
1s4w - hIG cytoplasmic domain]] - NMR
IG α-2b β-3
1kup, 1kuz – hIG proximal domain – NMR
1m8o - hIG cytoplasmic domain – NMR
2k9j, 2knc - hIG transmembrane domain – NMR
1tye, 3fcu – hIG + Mg
3fc3 – hIG (mutant) + Mg
2vc2, 2vdk, 2vdl, 3nid, 3nif, 3nig – hIG headpiece + antibody + Mg
2vdm, 2vdn, 3t3m, 3t3p – hIG headpiece + antibody + antagonist + Mg
2vdo, 2vdp, 2vdq, 2vdr – hIG headpiece + antibody + fibrinogen peptide + Mg
IG α-4 β-7
3v4p - hIG headpiece (mutant) + antibody + Mg
3v4v - hIG headpiece (mutant) + antibody + inhibitor + Mg
IG α-5 β-1
3vi3 - hIG headpiece + antibody + Mg
3vi4 - hIG headpiece + antibody + peptide + Mg
IG α-5 β-3
3ije – hIG + Ca
1m1x - hIG extracellular domain + Mn
1u8c – hIG psi domain + Ca
1jv2 - hIG I domain + platelet membrane glycoprotein IIIA + Ca
1l5g - hIG I domain + tripeptide + Mn
IG α-X β-2
3k6s, 3k71, 3k72 – hIG + Mg
IG β-2
2p26, 2p28 – hIG phe2 + phe3 domains
IG β-3
1s4x, 2kv9, 2ljd, 2lje, 2ljf – hIG cytoplasmic domain – NMR
2rmz, 2rn0 – hIG transmembrane domain – NMR
2l91 - hIG transmembrane domain (mutant) – NMR
IG β-4
2f7q, 3f7r - hIG fibronectin type III domain
2yrz – hIG fibronectin type III domain – NMR
3f7p - hIG fibronectin type III domain + plectin-1 + Ca
3fq4, 3fso, 3h6a – hIG Calx-β domain
