Sandbox 39
From Proteopedia
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ADK is a protein made up of 214 amino acids. The <scene name='Sandbox_39/Adenylate_kinase_main_chain2/1'>mainchain</scene> of adenylate kinase can be seen here in purple with the ligand in the middle of the protein. The <scene name='Sandbox_39/Adenylate_kinase_beta_sheets2/1'>secondary structure</scene> contains 12 alpha helices (light blue) and 7 beta sheets (yellow). The <scene name='Sandbox_39/Adenylate_kinase_hbonds2/1'>backbone hydrogen bonds</scene> hold the protein together. | ADK is a protein made up of 214 amino acids. The <scene name='Sandbox_39/Adenylate_kinase_main_chain2/1'>mainchain</scene> of adenylate kinase can be seen here in purple with the ligand in the middle of the protein. The <scene name='Sandbox_39/Adenylate_kinase_beta_sheets2/1'>secondary structure</scene> contains 12 alpha helices (light blue) and 7 beta sheets (yellow). The <scene name='Sandbox_39/Adenylate_kinase_hbonds2/1'>backbone hydrogen bonds</scene> hold the protein together. | ||
| + | <scene name='Sandbox_39/Adenylate_kinase_solv_w_lig/1'>solvent with ligand</scene> | ||
| - | + | <scene name='Sandbox_39/Adenylate_kinase_solvent/1'>solvent</scene> | |
| - | + | ||
<scene name='Sandbox_39/Adenylate_kinase_hydro_resid4/1'>hydrophobic residues</scene> | <scene name='Sandbox_39/Adenylate_kinase_hydro_resid4/1'>hydrophobic residues</scene> | ||
Revision as of 19:04, 18 October 2012
| Please do NOT make changes to this Sandbox. Sandboxes 30-60 are reserved for use by Biochemistry 410 & 412 at Messiah College taught by Dr. Hannah Tims during Fall 2012 and Spring 2013. |
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Description
Adenylate kinase, commonly known as ADK, is a phosphotransferase enzyme. It has two important roles in various organisms. First, ADK plays an important role in nucleotide metabolism and synthesis. It also has a role in cellular energetics and homeostasis by phosphotransfer networks. Adenylate kinase catalyzes the reaction that forms ADP. The reaction is ATP + AMP = 2 ADP. In this catalyzed reaction, ADK molecules bind to AMP molecules and increase its binding affinity for ATP over other phosphate groups. However, adenylate kinase is also found in other molecules such as bacteria and yeast. ADK plays similar roles in bacteria and yeast, in that it involves cellular metabolism and energy. The following images highlight the structure of Adenylate kinase from Yersinia pestis, commonly known as yeast.
Structure
ADK is a protein made up of 214 amino acids. The of adenylate kinase can be seen here in purple with the ligand in the middle of the protein. The contains 12 alpha helices (light blue) and 7 beta sheets (yellow). The hold the protein together.
