1kxu
From Proteopedia
(New page: 200px<br /> <applet load="1kxu" size="450" color="white" frame="true" align="right" spinBox="true" caption="1kxu, resolution 2.60Å" /> '''CYCLIN H, A POSITIV...) |
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| - | [[Image:1kxu.gif|left|200px]]<br /> | + | [[Image:1kxu.gif|left|200px]]<br /><applet load="1kxu" size="350" color="white" frame="true" align="right" spinBox="true" |
| - | <applet load="1kxu" size=" | + | |
caption="1kxu, resolution 2.60Å" /> | caption="1kxu, resolution 2.60Å" /> | ||
'''CYCLIN H, A POSITIVE REGULATORY SUBUNIT OF CDK ACTIVATING KINASE'''<br /> | '''CYCLIN H, A POSITIVE REGULATORY SUBUNIT OF CDK ACTIVATING KINASE'''<br /> | ||
==Overview== | ==Overview== | ||
| - | Cyclin-dependent kinases (CDKs), which play a key role in cell cycle | + | Cyclin-dependent kinases (CDKs), which play a key role in cell cycle control, are activated by the CDK activating kinase (CAK), which activates cyclin-bound CDKs by phosphorylation at a specific threonine residue. Vertebrate CAK contains two key components: a kinase subunit with homology to its substrate CDKs and a regulatory subunit with homology to cyclins. We have determined the X-ray crystal structure of the regulatory subunit of CAK, cyclin H, at 2.6 A resolution. Cyclin H contains two alpha-helical core domains with a fold similar to that of cyclin A, a regulatory subunit of CAK substrate CDK2, and of TFIIB, a transcription factor. Outside of the core domains, the N- and C-terminal regions of the three structures are completely different. The conformational differences between cyclin H and A structures may reflect functional differences between the two cyclins. |
==About this Structure== | ==About this Structure== | ||
| - | 1KXU is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http:// | + | 1KXU is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1KXU OCA]. |
==Reference== | ==Reference== | ||
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[[Category: Homo sapiens]] | [[Category: Homo sapiens]] | ||
[[Category: Single protein]] | [[Category: Single protein]] | ||
| - | [[Category: Chamberin, H | + | [[Category: Chamberin, H M.]] |
| - | [[Category: Kim, K | + | [[Category: Kim, K K.]] |
| - | [[Category: Kim, S | + | [[Category: Kim, S H.]] |
| - | [[Category: Morgan, D | + | [[Category: Morgan, D O.]] |
[[Category: alpha-helical structure]] | [[Category: alpha-helical structure]] | ||
[[Category: cell cycle]] | [[Category: cell cycle]] | ||
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[[Category: regulatory protein]] | [[Category: regulatory protein]] | ||
| - | ''Page seeded by [http:// | + | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Feb 21 13:39:11 2008'' |
Revision as of 11:39, 21 February 2008
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CYCLIN H, A POSITIVE REGULATORY SUBUNIT OF CDK ACTIVATING KINASE
Overview
Cyclin-dependent kinases (CDKs), which play a key role in cell cycle control, are activated by the CDK activating kinase (CAK), which activates cyclin-bound CDKs by phosphorylation at a specific threonine residue. Vertebrate CAK contains two key components: a kinase subunit with homology to its substrate CDKs and a regulatory subunit with homology to cyclins. We have determined the X-ray crystal structure of the regulatory subunit of CAK, cyclin H, at 2.6 A resolution. Cyclin H contains two alpha-helical core domains with a fold similar to that of cyclin A, a regulatory subunit of CAK substrate CDK2, and of TFIIB, a transcription factor. Outside of the core domains, the N- and C-terminal regions of the three structures are completely different. The conformational differences between cyclin H and A structures may reflect functional differences between the two cyclins.
About this Structure
1KXU is a Single protein structure of sequence from Homo sapiens. Full crystallographic information is available from OCA.
Reference
Three-dimensional structure of human cyclin H, a positive regulator of the CDK-activating kinase., Kim KK, Chamberlin HM, Morgan DO, Kim SH, Nat Struct Biol. 1996 Oct;3(10):849-55. PMID:8836101
Page seeded by OCA on Thu Feb 21 13:39:11 2008
