1ayo
From Proteopedia
(New page: 200px<br /> <applet load="1ayo" size="450" color="white" frame="true" align="right" spinBox="true" caption="1ayo, resolution 1.90Å" /> '''RECEPTOR BINDING DO...) |
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==About this Structure== | ==About this Structure== | ||
| - | 1AYO is a [[http://en.wikipedia.org/wiki/Single_protein Single protein]] structure of sequence from [[http://en.wikipedia.org/wiki/Bos_taurus Bos taurus]] with CA as [[http://en.wikipedia.org/wiki/ligand ligand]]. Full crystallographic information is available from [[http://ispc.weizmann.ac.il/oca-bin/ocashort?id=1AYO OCA]]. | + | 1AYO is a [[http://en.wikipedia.org/wiki/Single_protein Single protein]] structure of sequence from [[http://en.wikipedia.org/wiki/Bos_taurus Bos taurus]] with CA as [[http://en.wikipedia.org/wiki/ligand ligand]]. Structure known Active Sites: S1 and S2. Full crystallographic information is available from [[http://ispc.weizmann.ac.il/oca-bin/ocashort?id=1AYO OCA]]. |
==Reference== | ==Reference== | ||
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[[Category: receptor binding domain]] | [[Category: receptor binding domain]] | ||
| - | ''Page seeded by [http://ispc.weizmann.ac.il/oca OCA ] on | + | ''Page seeded by [http://ispc.weizmann.ac.il/oca OCA ] on Tue Oct 30 14:34:38 2007'' |
Revision as of 12:29, 30 October 2007
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RECEPTOR BINDING DOMAIN OF BOVINE ALPHA-2-MACROGLOBULIN
Overview
BACKGROUND: The large plasma proteinase inhibitors of the alpha, 2-macroglobulin superfamily inhibit proteinases by capturing them within a, central cavity of the inhibitor molecule. After reaction with the, proteinase, the alpha-macroglobulin-proteinase complex binds to the, alpha-macroglobulin receptor, present in the liver and other tissues, and, becomes endocytosed and rapidly removed from the circulation. The complex, binds to the receptor via recognition sites located on a separate domain, of approximately 138 residues positioned at the C terminus of the, alpha-macroglobulin subunit. RESULTS: The crystal structure of the, receptor-binding domain of bovine alpha 2-macroglobulin (bRBD) has been, determined at a resolution of 1.9 A. The domain primarily comprises a, nine-strand beta ... [(full description)]
About this Structure
1AYO is a [Single protein] structure of sequence from [Bos taurus] with CA as [ligand]. Structure known Active Sites: S1 and S2. Full crystallographic information is available from [OCA].
Reference
Crystal structure of the receptor-binding domain of alpha 2-macroglobulin., Jenner L, Husted L, Thirup S, Sottrup-Jensen L, Nyborg J, Structure. 1998 May 15;6(5):595-604. PMID:9634697
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