1kzq
From Proteopedia
(New page: 200px<br /><applet load="1kzq" size="450" color="white" frame="true" align="right" spinBox="true" caption="1kzq, resolution 1.7Å" /> '''crystal structure of ...) |
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| - | [[Image:1kzq.jpg|left|200px]]<br /><applet load="1kzq" size=" | + | [[Image:1kzq.jpg|left|200px]]<br /><applet load="1kzq" size="350" color="white" frame="true" align="right" spinBox="true" |
caption="1kzq, resolution 1.7Å" /> | caption="1kzq, resolution 1.7Å" /> | ||
'''crystal structure of a parasite protein'''<br /> | '''crystal structure of a parasite protein'''<br /> | ||
==Overview== | ==Overview== | ||
| - | Toxoplasma gondii is a persistent protozoan parasite capable of infecting | + | Toxoplasma gondii is a persistent protozoan parasite capable of infecting almost any warm-blooded vertebrate. The surface of Toxoplasma is coated with a family of developmentally regulated glycosylphosphatidylinositol (GPI)-linked proteins (SRSs), of which SAG1 is the prototypic member. SRS proteins mediate attachment to host cells and interface with the host immune response to regulate the virulence of the parasite. The 1.7 A structure of the immunodominant SAG1 antigen reveals a homodimeric configuration in which the dimeric interface is mediated by an extended beta-sheet that forms a deep groove lined with positively charged amino acids. This basic groove seems to be conserved among SRS proteins and potentially serves as a sulfated proteoglycan-binding site on target cell surfaces, thus rationalizing the promiscuous attachment properties of Toxoplasma to a broad range of host cell types. |
==About this Structure== | ==About this Structure== | ||
| - | 1KZQ is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Toxoplasma_gondii Toxoplasma gondii]. Full crystallographic information is available from [http:// | + | 1KZQ is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Toxoplasma_gondii Toxoplasma gondii]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1KZQ OCA]. |
==Reference== | ==Reference== | ||
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[[Category: Single protein]] | [[Category: Single protein]] | ||
[[Category: Toxoplasma gondii]] | [[Category: Toxoplasma gondii]] | ||
| - | [[Category: Boothroyd, J | + | [[Category: Boothroyd, J C.]] |
| - | [[Category: Garcia, K | + | [[Category: Garcia, K C.]] |
| - | [[Category: Grigg, M | + | [[Category: Grigg, M E.]] |
[[Category: He, X.]] | [[Category: He, X.]] | ||
[[Category: crystal structure]] | [[Category: crystal structure]] | ||
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[[Category: toxoplasma gondii]] | [[Category: toxoplasma gondii]] | ||
| - | ''Page seeded by [http:// | + | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Feb 21 13:39:42 2008'' |
Revision as of 11:39, 21 February 2008
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crystal structure of a parasite protein
Overview
Toxoplasma gondii is a persistent protozoan parasite capable of infecting almost any warm-blooded vertebrate. The surface of Toxoplasma is coated with a family of developmentally regulated glycosylphosphatidylinositol (GPI)-linked proteins (SRSs), of which SAG1 is the prototypic member. SRS proteins mediate attachment to host cells and interface with the host immune response to regulate the virulence of the parasite. The 1.7 A structure of the immunodominant SAG1 antigen reveals a homodimeric configuration in which the dimeric interface is mediated by an extended beta-sheet that forms a deep groove lined with positively charged amino acids. This basic groove seems to be conserved among SRS proteins and potentially serves as a sulfated proteoglycan-binding site on target cell surfaces, thus rationalizing the promiscuous attachment properties of Toxoplasma to a broad range of host cell types.
About this Structure
1KZQ is a Single protein structure of sequence from Toxoplasma gondii. Full crystallographic information is available from OCA.
Reference
Structure of the immunodominant surface antigen from the Toxoplasma gondii SRS superfamily., He XL, Grigg ME, Boothroyd JC, Garcia KC, Nat Struct Biol. 2002 Aug;9(8):606-11. PMID:12091874
Page seeded by OCA on Thu Feb 21 13:39:42 2008
