1ay6
From Proteopedia
(New page: 200px<br /> <applet load="1ay6" size="450" color="white" frame="true" align="right" spinBox="true" caption="1ay6, resolution 1.8Å" /> '''THROMBIN INHIBITOR F...) |
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==About this Structure== | ==About this Structure== | ||
| - | 1AY6 is a [[http://en.wikipedia.org/wiki/Protein_complex Protein complex]] structure of sequences from [[http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]] with HHO as [[http://en.wikipedia.org/wiki/ligand ligand]]. Active as [[http://en.wikipedia.org/wiki/ ]], with EC number [[http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.4.21.5 3.4.21.5]]. Full crystallographic information is available from [[http://ispc.weizmann.ac.il/oca-bin/ocashort?id=1AY6 OCA]]. | + | 1AY6 is a [[http://en.wikipedia.org/wiki/Protein_complex Protein complex]] structure of sequences from [[http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]] with HHO as [[http://en.wikipedia.org/wiki/ligand ligand]]. Active as [[http://en.wikipedia.org/wiki/Thrombin Thrombin]], with EC number [[http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.4.21.5 3.4.21.5]]. Structure known Active Site: CAT. Full crystallographic information is available from [[http://ispc.weizmann.ac.il/oca-bin/ocashort?id=1AY6 OCA]]. |
==Reference== | ==Reference== | ||
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[[Category: Homo sapiens]] | [[Category: Homo sapiens]] | ||
[[Category: Protein complex]] | [[Category: Protein complex]] | ||
| + | [[Category: Thrombin]] | ||
[[Category: Ganesh, V.]] | [[Category: Ganesh, V.]] | ||
[[Category: Maryanoff, B.E.]] | [[Category: Maryanoff, B.E.]] | ||
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[[Category: hydrolase]] | [[Category: hydrolase]] | ||
| - | ''Page seeded by [http://ispc.weizmann.ac.il/oca OCA ] on | + | ''Page seeded by [http://ispc.weizmann.ac.il/oca OCA ] on Tue Oct 30 14:34:51 2007'' |
Revision as of 12:30, 30 October 2007
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THROMBIN INHIBITOR FROM THEONALLA, CYCLOTHEANAMIDE-BASED MACROCYCLIC TRIPEPTIDE MOTIF
Overview
The macrocyclic peptide cyclotheonamide A (CtA), isolated from the marine, sponge Theonella sp., represents an unusual class of serine protease, inhibitor. A complex of this inhibitor with human alpha-thrombin, a, protease central to the bioregulation of thrombosis and hemostasis, was, studied by x-ray crystallography. This work (2.3-A resolution) confirms, the structure of CtA and reveals intimate details about its molecular, recognition within the enzyme active site. Interactions due to the, "Pro-Arg motif" (Arg occupancy of the S1 specificity pocket; formation of, a hydrogen-bonded two-strand antiparallel beta-sheet with Ser214-Gly216), and the alpha-keto amide group of CtA are primarily responsible for, binding to thrombin, with the alpha-keto amide serving as a, transition-state ... [(full description)]
About this Structure
1AY6 is a [Protein complex] structure of sequences from [Homo sapiens] with HHO as [ligand]. Active as [Thrombin], with EC number [3.4.21.5]. Structure known Active Site: CAT. Full crystallographic information is available from [OCA].
Reference
Molecular basis for the inhibition of human alpha-thrombin by the macrocyclic peptide cyclotheonamide A., Maryanoff BE, Qiu X, Padmanabhan KP, Tulinsky A, Almond HR Jr, Andrade-Gordon P, Greco MN, Kauffman JA, Nicolaou KC, Liu A, et al., Proc Natl Acad Sci U S A. 1993 Sep 1;90(17):8048-52. PMID:8367461
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