2x0w
From Proteopedia
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==About this Structure== | ==About this Structure== | ||
| - | [[2x0w]] is a 2 chain structure | + | [[2x0w]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2X0W OCA]. |
==See Also== | ==See Also== | ||
Revision as of 05:41, 20 October 2012
Contents |
STRUCTURE OF THE P53 CORE DOMAIN MUTANT Y220C BOUND TO 5,6-DIMETHOXY-2-METHYLBENZOTHIAZOLE
Template:ABSTRACT PUBMED 20142040
About this Structure
2x0w is a 2 chain structure with sequence from Homo sapiens. Full crystallographic information is available from OCA.
See Also
Reference
- Basse N, Kaar JL, Settanni G, Joerger AC, Rutherford TJ, Fersht AR. Toward the rational design of p53-stabilizing drugs: probing the surface of the oncogenic Y220C mutant. Chem Biol. 2010 Jan 29;17(1):46-56. PMID:20142040 doi:10.1016/j.chembiol.2009.12.011
- Joerger AC, Ang HC, Fersht AR. Structural basis for understanding oncogenic p53 mutations and designing rescue drugs. Proc Natl Acad Sci U S A. 2006 Oct 10;103(41):15056-61. Epub 2006 Oct 2. PMID:17015838
Categories: Homo sapiens | Basse, N. | Fersht, A R. | Joerger, A C. | Kaar, J L. | Activator | Apoptosis | Cancer | Cell cycle | Drug discovery | Host-virus interaction | Li-fraumeni syndrome | Protein stabilization | Surface crevice | Transcription | Transcription factor | Transcription regulation | Tumor suppressor
