1l0x
From Proteopedia
(New page: 200px<br /><applet load="1l0x" size="450" color="white" frame="true" align="right" spinBox="true" caption="1l0x, resolution 2.8Å" /> '''TCR beta chain comple...) |
|||
| Line 1: | Line 1: | ||
| - | [[Image:1l0x.gif|left|200px]]<br /><applet load="1l0x" size=" | + | [[Image:1l0x.gif|left|200px]]<br /><applet load="1l0x" size="350" color="white" frame="true" align="right" spinBox="true" |
caption="1l0x, resolution 2.8Å" /> | caption="1l0x, resolution 2.8Å" /> | ||
'''TCR beta chain complexed with streptococcal superantigen SpeA'''<br /> | '''TCR beta chain complexed with streptococcal superantigen SpeA'''<br /> | ||
==Overview== | ==Overview== | ||
| - | Superantigens (SAGs) crosslink MHC class II and TCR molecules, resulting | + | Superantigens (SAGs) crosslink MHC class II and TCR molecules, resulting in an overstimulation of T cells associated with human disease. SAGs interact with several different surfaces on MHC molecules, necessitating the formation of multiple distinct MHC-SAG-TCR ternary signaling complexes. Variability in SAG-TCR binding modes could also contribute to the structural heterogeneity of SAG-dependent signaling complexes. We report crystal structures of the streptococcal SAGs SpeA and SpeC in complex with their corresponding TCR beta chain ligands that reveal distinct TCR binding modes. The SpeC-TCR beta chain complex structure, coupled with the recently determined SpeC-HLA-DR2a complex structure, provides a model for a novel T cell signaling complex that precludes direct TCR-MHC interactions. Thus, highly efficient T cell activation may be achieved through structurally diverse strategies of TCR ligation. |
==About this Structure== | ==About this Structure== | ||
| - | 1L0X is a [http://en.wikipedia.org/wiki/Protein_complex Protein complex] structure of sequences from [http://en.wikipedia.org/wiki/Mus_musculus Mus musculus] and [http://en.wikipedia.org/wiki/Streptococcus_pyogenes Streptococcus pyogenes] with GOL as [http://en.wikipedia.org/wiki/ligand ligand]. Full crystallographic information is available from [http:// | + | 1L0X is a [http://en.wikipedia.org/wiki/Protein_complex Protein complex] structure of sequences from [http://en.wikipedia.org/wiki/Mus_musculus Mus musculus] and [http://en.wikipedia.org/wiki/Streptococcus_pyogenes Streptococcus pyogenes] with <scene name='pdbligand=GOL:'>GOL</scene> as [http://en.wikipedia.org/wiki/ligand ligand]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1L0X OCA]. |
==Reference== | ==Reference== | ||
| Line 15: | Line 15: | ||
[[Category: Streptococcus pyogenes]] | [[Category: Streptococcus pyogenes]] | ||
[[Category: Li, H.]] | [[Category: Li, H.]] | ||
| - | [[Category: Mariuzza, R | + | [[Category: Mariuzza, R A.]] |
| - | [[Category: Sundberg, E | + | [[Category: Sundberg, E J.]] |
[[Category: GOL]] | [[Category: GOL]] | ||
[[Category: superantigen]] | [[Category: superantigen]] | ||
[[Category: tcr]] | [[Category: tcr]] | ||
| - | ''Page seeded by [http:// | + | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Feb 21 13:40:02 2008'' |
Revision as of 11:40, 21 February 2008
|
TCR beta chain complexed with streptococcal superantigen SpeA
Overview
Superantigens (SAGs) crosslink MHC class II and TCR molecules, resulting in an overstimulation of T cells associated with human disease. SAGs interact with several different surfaces on MHC molecules, necessitating the formation of multiple distinct MHC-SAG-TCR ternary signaling complexes. Variability in SAG-TCR binding modes could also contribute to the structural heterogeneity of SAG-dependent signaling complexes. We report crystal structures of the streptococcal SAGs SpeA and SpeC in complex with their corresponding TCR beta chain ligands that reveal distinct TCR binding modes. The SpeC-TCR beta chain complex structure, coupled with the recently determined SpeC-HLA-DR2a complex structure, provides a model for a novel T cell signaling complex that precludes direct TCR-MHC interactions. Thus, highly efficient T cell activation may be achieved through structurally diverse strategies of TCR ligation.
About this Structure
1L0X is a Protein complex structure of sequences from Mus musculus and Streptococcus pyogenes with as ligand. Full crystallographic information is available from OCA.
Reference
Structures of two streptococcal superantigens bound to TCR beta chains reveal diversity in the architecture of T cell signaling complexes., Sundberg EJ, Li H, Llera AS, McCormick JK, Tormo J, Schlievert PM, Karjalainen K, Mariuzza RA, Structure. 2002 May;10(5):687-99. PMID:12015151
Page seeded by OCA on Thu Feb 21 13:40:02 2008
