2ayk
From Proteopedia
(New page: 200px<br /> <applet load="2ayk" size="450" color="white" frame="true" align="right" spinBox="true" caption="2ayk" /> '''INHIBITOR-FREE CATALYTIC FRAGMENT OF HUMAN ...) |
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==About this Structure== | ==About this Structure== | ||
| - | 2AYK is a [[http://en.wikipedia.org/wiki/Single_protein Single protein]] structure of sequence from [[http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]] with ZN and CA as [[http://en.wikipedia.org/wiki/ligands ligands]]. Active as [[http://en.wikipedia.org/wiki/ ]], with EC number [[http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.4.24.7 3.4.24.7]]. Full crystallographic information is available from [[http://ispc.weizmann.ac.il/oca-bin/ocashort?id=2AYK OCA]]. | + | 2AYK is a [[http://en.wikipedia.org/wiki/Single_protein Single protein]] structure of sequence from [[http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]] with ZN and CA as [[http://en.wikipedia.org/wiki/ligands ligands]]. Active as [[http://en.wikipedia.org/wiki/Interstitial_collagenase Interstitial collagenase]], with EC number [[http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.4.24.7 3.4.24.7]]. Structure known Active Sites: CAB, ZNA and ZNB. Full crystallographic information is available from [[http://ispc.weizmann.ac.il/oca-bin/ocashort?id=2AYK OCA]]. |
==Reference== | ==Reference== | ||
High-resolution solution structure of the inhibitor-free catalytic fragment of human fibroblast collagenase determined by multidimensional NMR., Moy FJ, Chanda PK, Cosmi S, Pisano MR, Urbano C, Wilhelm J, Powers R, Biochemistry. 1998 Feb 10;37(6):1495-504. PMID:[http://ispc.weizmann.ac.il//pmbin/getpm?pmid=9484219 9484219] | High-resolution solution structure of the inhibitor-free catalytic fragment of human fibroblast collagenase determined by multidimensional NMR., Moy FJ, Chanda PK, Cosmi S, Pisano MR, Urbano C, Wilhelm J, Powers R, Biochemistry. 1998 Feb 10;37(6):1495-504. PMID:[http://ispc.weizmann.ac.il//pmbin/getpm?pmid=9484219 9484219] | ||
[[Category: Homo sapiens]] | [[Category: Homo sapiens]] | ||
| + | [[Category: Interstitial collagenase]] | ||
[[Category: Single protein]] | [[Category: Single protein]] | ||
[[Category: Moy, F.J.]] | [[Category: Moy, F.J.]] | ||
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[[Category: metalloprotease]] | [[Category: metalloprotease]] | ||
| - | ''Page seeded by [http://ispc.weizmann.ac.il/oca OCA ] on | + | ''Page seeded by [http://ispc.weizmann.ac.il/oca OCA ] on Tue Oct 30 14:35:02 2007'' |
Revision as of 12:30, 30 October 2007
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INHIBITOR-FREE CATALYTIC FRAGMENT OF HUMAN FIBROBLAST COLLAGENASE, NMR, MINIMIZED AVERAGE STRUCTURE
Overview
The high-resolution solution structure of the inhibitor-free catalytic, fragment of human fibroblast collagenase (MMP-1), a protein of 18.7 kDa, which is a member of the matrix metalloproteinase family, has been, determined using three-dimensional heteronuclear NMR spectroscopy. A total, of 30 structures were calculated by means of hybrid distance, geometry-simulated annealing using a total of 3333 experimental NMR, restraints, consisting of 2409 approximate interproton distance, restraints, 84 distance restraints for 42 backbone hydrogen bonds, 426, torsion angle restraints, 125 3JNH alpha restraints, 153 C alpha, restraints, and 136 C beta restraints. The atomic rms distribution about, the mean coordinate positions for the 30 structures for residues 7-137 and, 145-163 is 0.42 +/- 0.04 A ... [(full description)]
About this Structure
2AYK is a [Single protein] structure of sequence from [Homo sapiens] with ZN and CA as [ligands]. Active as [Interstitial collagenase], with EC number [3.4.24.7]. Structure known Active Sites: CAB, ZNA and ZNB. Full crystallographic information is available from [OCA].
Reference
High-resolution solution structure of the inhibitor-free catalytic fragment of human fibroblast collagenase determined by multidimensional NMR., Moy FJ, Chanda PK, Cosmi S, Pisano MR, Urbano C, Wilhelm J, Powers R, Biochemistry. 1998 Feb 10;37(6):1495-504. PMID:9484219
Page seeded by OCA on Tue Oct 30 14:35:02 2007
