2cki
From Proteopedia
(New page: 200px<br /> <applet load="2cki" size="450" color="white" frame="true" align="right" spinBox="true" caption="2cki, resolution 1.70Å" /> '''STRUCTURE OF ULILYS...) |
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==About this Structure== | ==About this Structure== | ||
| - | 2CKI is a [[http://en.wikipedia.org/wiki/Single_protein Single protein]] structure of sequence from [[http://en.wikipedia.org/wiki/Methanosarcina_acetivorans Methanosarcina acetivorans]] with CA, ZN, ARG and GOL as [[http://en.wikipedia.org/wiki/ligands ligands]]. Full crystallographic information is available from [[http://ispc.weizmann.ac.il/oca-bin/ocashort?id=2CKI OCA]]. | + | 2CKI is a [[http://en.wikipedia.org/wiki/Single_protein Single protein]] structure of sequence from [[http://en.wikipedia.org/wiki/Methanosarcina_acetivorans Methanosarcina acetivorans]] with CA, ZN, ARG and GOL as [[http://en.wikipedia.org/wiki/ligands ligands]]. Structure known Active Site: AC1. Full crystallographic information is available from [[http://ispc.weizmann.ac.il/oca-bin/ocashort?id=2CKI OCA]]. |
==Reference== | ==Reference== | ||
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[[Category: pappalysin]] | [[Category: pappalysin]] | ||
| - | ''Page seeded by [http://ispc.weizmann.ac.il/oca OCA ] on | + | ''Page seeded by [http://ispc.weizmann.ac.il/oca OCA ] on Tue Oct 30 14:35:10 2007'' |
Revision as of 12:30, 30 October 2007
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STRUCTURE OF ULILYSIN, A MEMBER OF THE PAPPALYSIN FAMILY OF METZINCIN METALLOENDOPEPTIDASES.
Overview
The metzincin clan encompasses several families of zinc-dependent, metalloproteases with proven function both in physiology and pathology., They act either as broad spectrum protein degraders or as sheddases, operating through limited proteolysis. Among the structurally, uncharacterized metzincin families are the pappalysins, of which the most, thoroughly studied member is human pregnancy-associated plasma protein A, (PAPP-A), a heavily glycosylated 170-kDa multidomain protein specifically, cleaving insulin-like growth factor (IGF)-binding proteins (IGFBPs)., Proulilysin is a 38-kDa archaeal protein that shares sequence similarity, with PAPP-A but encompasses only the pro-domain and the catalytic domain., It undergoes calcium-mediated autolytic activation, and the mature protein, adopts a ... [(full description)]
About this Structure
2CKI is a [Single protein] structure of sequence from [Methanosarcina acetivorans] with CA, ZN, ARG and GOL as [ligands]. Structure known Active Site: AC1. Full crystallographic information is available from [OCA].
Reference
Molecular analysis of ulilysin, the structural prototype of a new family of metzincin metalloproteases., Tallant C, Garcia-Castellanos R, Seco J, Baumann U, Gomis-Ruth FX, J Biol Chem. 2006 Jun 30;281(26):17920-8. Epub 2006 Apr 20. PMID:16627477
Page seeded by OCA on Tue Oct 30 14:35:10 2007
Categories: Methanosarcina acetivorans | Single protein | Baumann, U. | Garcia-Castellanos, R. | Gomis-Ruth, F.X. | Seco, J. | Tallant, C. | ARG | CA | GOL | ZN | Cancer | Hydrolase | Hypothetical protein | Igf | Igfbp protease | Metalloprotease | Metzincin | Pappalysin
