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1l2n
From Proteopedia
(New page: 200px<br /><applet load="1l2n" size="450" color="white" frame="true" align="right" spinBox="true" caption="1l2n" /> '''Smt3 Solution Structure'''<br /> ==Overview...) |
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| - | [[Image:1l2n.jpg|left|200px]]<br /><applet load="1l2n" size=" | + | [[Image:1l2n.jpg|left|200px]]<br /><applet load="1l2n" size="350" color="white" frame="true" align="right" spinBox="true" |
caption="1l2n" /> | caption="1l2n" /> | ||
'''Smt3 Solution Structure'''<br /> | '''Smt3 Solution Structure'''<br /> | ||
==Overview== | ==Overview== | ||
| - | Smt3 belongs to a growing family of ubiquitin-related proteins involved in | + | Smt3 belongs to a growing family of ubiquitin-related proteins involved in posttranslational protein modification. Independent studies demonstrate an essential function of Smt3 in the regulation of nucleocytoplasmic transport, and suggest a role in cell-cycle regulation. Here we report the high-resolution NMR structure of yeast Smt3 in the complex free form. Our comparison of the Smt3 NMR structure with the Smt3 crystal structure in complex with the C-Terminal Ulp1 protease domain revealed large structural differences in the binding surface, which is also involved in the Smt3-Ubc-9 interaction detected by NMR. The structural differences in the region indicate the important functions of conserved residues in less structurally defined sequences. |
==About this Structure== | ==About this Structure== | ||
| - | 1L2N is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Saccharomyces_cerevisiae Saccharomyces cerevisiae]. Full crystallographic information is available from [http:// | + | 1L2N is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Saccharomyces_cerevisiae Saccharomyces cerevisiae]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1L2N OCA]. |
==Reference== | ==Reference== | ||
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[[Category: ubiquitin-like protein]] | [[Category: ubiquitin-like protein]] | ||
| - | ''Page seeded by [http:// | + | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Feb 21 13:40:38 2008'' |
Revision as of 11:40, 21 February 2008
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Smt3 Solution Structure
Overview
Smt3 belongs to a growing family of ubiquitin-related proteins involved in posttranslational protein modification. Independent studies demonstrate an essential function of Smt3 in the regulation of nucleocytoplasmic transport, and suggest a role in cell-cycle regulation. Here we report the high-resolution NMR structure of yeast Smt3 in the complex free form. Our comparison of the Smt3 NMR structure with the Smt3 crystal structure in complex with the C-Terminal Ulp1 protease domain revealed large structural differences in the binding surface, which is also involved in the Smt3-Ubc-9 interaction detected by NMR. The structural differences in the region indicate the important functions of conserved residues in less structurally defined sequences.
About this Structure
1L2N is a Single protein structure of sequence from Saccharomyces cerevisiae. Full crystallographic information is available from OCA.
Reference
Solution structure of a yeast ubiquitin-like protein Smt3: the role of structurally less defined sequences in protein-protein recognitions., Sheng W, Liao X, Protein Sci. 2002 Jun;11(6):1482-91. PMID:12021447
Page seeded by OCA on Thu Feb 21 13:40:38 2008
