1la2
From Proteopedia
(New page: 200px<br /><applet load="1la2" size="450" color="white" frame="true" align="right" spinBox="true" caption="1la2, resolution 2.65Å" /> '''Structural analysis ...) |
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| - | [[Image:1la2.gif|left|200px]]<br /><applet load="1la2" size=" | + | [[Image:1la2.gif|left|200px]]<br /><applet load="1la2" size="350" color="white" frame="true" align="right" spinBox="true" |
caption="1la2, resolution 2.65Å" /> | caption="1la2, resolution 2.65Å" /> | ||
'''Structural analysis of Saccharomyces cerevisiae myo-inositol phosphate synthase'''<br /> | '''Structural analysis of Saccharomyces cerevisiae myo-inositol phosphate synthase'''<br /> | ||
==Overview== | ==Overview== | ||
| - | The New York Structural Genomics Research Consortium has targeted highly | + | The New York Structural Genomics Research Consortium has targeted highly conserved but uncharacterized enzyme families for structure determination. As part of this effort, the 2.65-A crystal structure has been determined for Saccharomyces cerevisiae myo-inositol 1-phosphate synthase (MIP), an essential enzyme that catalyzes critical steps in inositol biosynthesis. The structure determination of four independent monomers in the asymmetric unit (240 kDa) reveals atomic details and residue composition for the partially closed NAD-containing active sites in apo-configuration. The structure further reveals extensive interactions involved in tetrameric assembly of the enzyme complex. |
==About this Structure== | ==About this Structure== | ||
| - | 1LA2 is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Saccharomyces_cerevisiae Saccharomyces cerevisiae] with NAD as [http://en.wikipedia.org/wiki/ligand ligand]. Active as [http://en.wikipedia.org/wiki/Inositol-3-phosphate_synthase Inositol-3-phosphate synthase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=5.5.1.4 5.5.1.4] Full crystallographic information is available from [http:// | + | 1LA2 is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Saccharomyces_cerevisiae Saccharomyces cerevisiae] with <scene name='pdbligand=NAD:'>NAD</scene> as [http://en.wikipedia.org/wiki/ligand ligand]. Active as [http://en.wikipedia.org/wiki/Inositol-3-phosphate_synthase Inositol-3-phosphate synthase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=5.5.1.4 5.5.1.4] Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1LA2 OCA]. |
==Reference== | ==Reference== | ||
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[[Category: Single protein]] | [[Category: Single protein]] | ||
[[Category: Beckwith, A.]] | [[Category: Beckwith, A.]] | ||
| - | [[Category: Buglino, J | + | [[Category: Buglino, J A.]] |
| - | [[Category: Burley, S | + | [[Category: Burley, S K.]] |
[[Category: Chadna, T.]] | [[Category: Chadna, T.]] | ||
[[Category: Kniewel, R.]] | [[Category: Kniewel, R.]] | ||
| - | [[Category: Lima, C | + | [[Category: Lima, C D.]] |
| - | [[Category: NYSGXRC, New | + | [[Category: NYSGXRC, New York Structural GenomiX Research Consortium.]] |
[[Category: Shen, V.]] | [[Category: Shen, V.]] | ||
[[Category: NAD]] | [[Category: NAD]] | ||
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[[Category: yeast]] | [[Category: yeast]] | ||
| - | ''Page seeded by [http:// | + | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Feb 21 13:42:58 2008'' |
Revision as of 11:43, 21 February 2008
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Structural analysis of Saccharomyces cerevisiae myo-inositol phosphate synthase
Overview
The New York Structural Genomics Research Consortium has targeted highly conserved but uncharacterized enzyme families for structure determination. As part of this effort, the 2.65-A crystal structure has been determined for Saccharomyces cerevisiae myo-inositol 1-phosphate synthase (MIP), an essential enzyme that catalyzes critical steps in inositol biosynthesis. The structure determination of four independent monomers in the asymmetric unit (240 kDa) reveals atomic details and residue composition for the partially closed NAD-containing active sites in apo-configuration. The structure further reveals extensive interactions involved in tetrameric assembly of the enzyme complex.
About this Structure
1LA2 is a Single protein structure of sequence from Saccharomyces cerevisiae with as ligand. Active as Inositol-3-phosphate synthase, with EC number 5.5.1.4 Full crystallographic information is available from OCA.
Reference
Structural analysis of Saccharomyces cerevisiae myo-inositol phosphate synthase., Kniewel R, Buglino JA, Shen V, Chadha T, Beckwith A, Lima CD, J Struct Funct Genomics. 2002;2(3):129-34. PMID:12836703
Page seeded by OCA on Thu Feb 21 13:42:58 2008
Categories: Inositol-3-phosphate synthase | Saccharomyces cerevisiae | Single protein | Beckwith, A. | Buglino, J A. | Burley, S K. | Chadna, T. | Kniewel, R. | Lima, C D. | NYSGXRC, New York Structural GenomiX Research Consortium. | Shen, V. | NAD | Ino1 | Inositol | Metabolism | New york structural genomix research consortium | Nysgxrc | Protein structure initiative | Psi | Structural genomics | Yeast
