1lfa
From Proteopedia
(New page: 200px<br /> <applet load="1lfa" size="450" color="white" frame="true" align="right" spinBox="true" caption="1lfa, resolution 1.8Å" /> '''CD11A I-DOMAIN WITH ...) |
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| - | [[Image:1lfa.gif|left|200px]]<br /> | + | [[Image:1lfa.gif|left|200px]]<br /><applet load="1lfa" size="350" color="white" frame="true" align="right" spinBox="true" |
| - | <applet load="1lfa" size=" | + | |
caption="1lfa, resolution 1.8Å" /> | caption="1lfa, resolution 1.8Å" /> | ||
'''CD11A I-DOMAIN WITH BOUND MN++'''<br /> | '''CD11A I-DOMAIN WITH BOUND MN++'''<br /> | ||
==Overview== | ==Overview== | ||
| - | We report the 1.8-A crystal structure of the CD11a I-domain with bound | + | We report the 1.8-A crystal structure of the CD11a I-domain with bound manganese ion. The CD11a I-domain contains binding sites for intercellular adhesion molecules 1 and 3 and can exist in both low- and high-affinity states. The metal-bound form reported here is likely to represent a high-affinity state. The CD11a I-domain structure reveals a strained hydrophobic ridge adjacent to the bound metal ion that may serve as a ligand-binding surface and is likely to rearrange in the absence of bound metal ion. The CD11a I-domain is homologous to domains found in von Willebrand factor, and mapping of mutations found in types 2a and 2b von Willebrand disease onto this structure allows consideration of the molecular basis of these forms of the disease. |
==About this Structure== | ==About this Structure== | ||
| - | 1LFA is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] with MN and CL as [http://en.wikipedia.org/wiki/ligands ligands]. Full crystallographic information is available from [http:// | + | 1LFA is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] with <scene name='pdbligand=MN:'>MN</scene> and <scene name='pdbligand=CL:'>CL</scene> as [http://en.wikipedia.org/wiki/ligands ligands]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1LFA OCA]. |
==Reference== | ==Reference== | ||
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[[Category: Homo sapiens]] | [[Category: Homo sapiens]] | ||
[[Category: Single protein]] | [[Category: Single protein]] | ||
| - | [[Category: Leahy, D | + | [[Category: Leahy, D J.]] |
[[Category: Qu, A.]] | [[Category: Qu, A.]] | ||
[[Category: CL]] | [[Category: CL]] | ||
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[[Category: cell adhesion]] | [[Category: cell adhesion]] | ||
| - | ''Page seeded by [http:// | + | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Feb 21 13:44:26 2008'' |
Revision as of 11:44, 21 February 2008
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CD11A I-DOMAIN WITH BOUND MN++
Overview
We report the 1.8-A crystal structure of the CD11a I-domain with bound manganese ion. The CD11a I-domain contains binding sites for intercellular adhesion molecules 1 and 3 and can exist in both low- and high-affinity states. The metal-bound form reported here is likely to represent a high-affinity state. The CD11a I-domain structure reveals a strained hydrophobic ridge adjacent to the bound metal ion that may serve as a ligand-binding surface and is likely to rearrange in the absence of bound metal ion. The CD11a I-domain is homologous to domains found in von Willebrand factor, and mapping of mutations found in types 2a and 2b von Willebrand disease onto this structure allows consideration of the molecular basis of these forms of the disease.
About this Structure
1LFA is a Single protein structure of sequence from Homo sapiens with and as ligands. Full crystallographic information is available from OCA.
Reference
Crystal structure of the I-domain from the CD11a/CD18 (LFA-1, alpha L beta 2) integrin., Qu A, Leahy DJ, Proc Natl Acad Sci U S A. 1995 Oct 24;92(22):10277-81. PMID:7479767
Page seeded by OCA on Thu Feb 21 13:44:26 2008
Categories: Homo sapiens | Single protein | Leahy, D J. | Qu, A. | CL | MN | Cell adhesion
