1lj9
From Proteopedia
(New page: 200px<br /><applet load="1lj9" size="450" color="white" frame="true" align="right" spinBox="true" caption="1lj9, resolution 1.60Å" /> '''The crystal structur...) |
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| - | [[Image:1lj9.gif|left|200px]]<br /><applet load="1lj9" size=" | + | [[Image:1lj9.gif|left|200px]]<br /><applet load="1lj9" size="350" color="white" frame="true" align="right" spinBox="true" |
caption="1lj9, resolution 1.60Å" /> | caption="1lj9, resolution 1.60Å" /> | ||
'''The crystal structure of the transcriptional regulator SlyA'''<br /> | '''The crystal structure of the transcriptional regulator SlyA'''<br /> | ||
==Overview== | ==Overview== | ||
| - | The crystal structure of a SlyA transcriptional regulator at 1.6 A | + | The crystal structure of a SlyA transcriptional regulator at 1.6 A resolution is presented, and structural relationships between members of the MarR/SlyA family are discussed. The SlyA family, which includes SlyA, Rap, Hor, and RovA proteins, is widely distributed in bacterial and archaeal genomes. Current evidence suggests that SlyA-like factors act as repressors, activators, and modulators of gene transcription. These proteins have been shown to up-regulate the expression of molecular chaperones, acid-resistance proteins, and cytolysin, and down-regulate several biosynthetic enzymes. The structure of SlyA from Enterococcus faecalis, determined as a part of an ongoing structural genomics initiative (www.mcsg.anl.gov), revealed the same winged helix DNA-binding motif that was recently found in the MarR repressor from Escherichia coli and the MexR repressor from Pseudomonas aeruginosa, a sequence homologue of MarR. Phylogenetic analysis of the MarR/SlyA family suggests that Sly is placed between the SlyA and MarR subfamilies and shows significant sequence similarity to members of both subfamilies. |
==About this Structure== | ==About this Structure== | ||
| - | 1LJ9 is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Enterococcus_faecalis Enterococcus faecalis]. Full crystallographic information is available from [http:// | + | 1LJ9 is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Enterococcus_faecalis Enterococcus faecalis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1LJ9 OCA]. |
==Reference== | ==Reference== | ||
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[[Category: Gornicki, P.]] | [[Category: Gornicki, P.]] | ||
[[Category: Joachimiak, A.]] | [[Category: Joachimiak, A.]] | ||
| - | [[Category: MCSG, Midwest | + | [[Category: MCSG, Midwest Center for Structural Genomics.]] |
| - | [[Category: Wu, R | + | [[Category: Wu, R Y.]] |
| - | [[Category: Zhang, R | + | [[Category: Zhang, R G.]] |
[[Category: hth dna binding protein]] | [[Category: hth dna binding protein]] | ||
[[Category: mcsg]] | [[Category: mcsg]] | ||
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[[Category: structural genomics]] | [[Category: structural genomics]] | ||
| - | ''Page seeded by [http:// | + | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Feb 21 13:45:30 2008'' |
Revision as of 11:45, 21 February 2008
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The crystal structure of the transcriptional regulator SlyA
Overview
The crystal structure of a SlyA transcriptional regulator at 1.6 A resolution is presented, and structural relationships between members of the MarR/SlyA family are discussed. The SlyA family, which includes SlyA, Rap, Hor, and RovA proteins, is widely distributed in bacterial and archaeal genomes. Current evidence suggests that SlyA-like factors act as repressors, activators, and modulators of gene transcription. These proteins have been shown to up-regulate the expression of molecular chaperones, acid-resistance proteins, and cytolysin, and down-regulate several biosynthetic enzymes. The structure of SlyA from Enterococcus faecalis, determined as a part of an ongoing structural genomics initiative (www.mcsg.anl.gov), revealed the same winged helix DNA-binding motif that was recently found in the MarR repressor from Escherichia coli and the MexR repressor from Pseudomonas aeruginosa, a sequence homologue of MarR. Phylogenetic analysis of the MarR/SlyA family suggests that Sly is placed between the SlyA and MarR subfamilies and shows significant sequence similarity to members of both subfamilies.
About this Structure
1LJ9 is a Single protein structure of sequence from Enterococcus faecalis. Full crystallographic information is available from OCA.
Reference
Crystal structure of Enterococcus faecalis SlyA-like transcriptional factor., Wu RY, Zhang RG, Zagnitko O, Dementieva I, Maltzev N, Watson JD, Laskowski R, Gornicki P, Joachimiak A, J Biol Chem. 2003 May 30;278(22):20240-4. Epub 2003 Mar 20. PMID:12649270
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