1lm7
From Proteopedia
(New page: 200px<br /> <applet load="1lm7" size="450" color="white" frame="true" align="right" spinBox="true" caption="1lm7, resolution 3.00Å" /> '''Structures of two i...) |
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| - | [[Image:1lm7.gif|left|200px]]<br /> | + | [[Image:1lm7.gif|left|200px]]<br /><applet load="1lm7" size="350" color="white" frame="true" align="right" spinBox="true" |
| - | <applet load="1lm7" size=" | + | |
caption="1lm7, resolution 3.00Å" /> | caption="1lm7, resolution 3.00Å" /> | ||
'''Structures of two intermediate filament-binding fragments of desmoplakin reveal a unique repeat motif structure'''<br /> | '''Structures of two intermediate filament-binding fragments of desmoplakin reveal a unique repeat motif structure'''<br /> | ||
==Overview== | ==Overview== | ||
| - | Desmosomes are intercellular junctions in which cadherin cell adhesion | + | Desmosomes are intercellular junctions in which cadherin cell adhesion molecules are linked to the intermediate filament (IF) system. Desmoplakin is a member of the plakin family of IF-binding proteins. The C-terminal domain of desmoplakin (DPCT) mediates binding to IFs in desmosomes. The DPCT sequence contains three regions, termed A, B and C, consisting of 4.5 copies of a 38-amino acid repeat motif. We demonstrate that these regions form discrete subdomains that bind to IFs and report the crystal structures of domains B and C. In contrast to the elongated structures formed by other kinds of repeat motifs, the plakin repeats form a globular structure with a unique fold. A conserved basic groove found on the domain may represent an IF-binding site. |
==Disease== | ==Disease== | ||
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==About this Structure== | ==About this Structure== | ||
| - | 1LM7 is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http:// | + | 1LM7 is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1LM7 OCA]. |
==Reference== | ==Reference== | ||
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[[Category: Homo sapiens]] | [[Category: Homo sapiens]] | ||
[[Category: Single protein]] | [[Category: Single protein]] | ||
| - | [[Category: Choi, H | + | [[Category: Choi, H J.]] |
| - | [[Category: Green, K | + | [[Category: Green, K J.]] |
[[Category: Park-Snyder, S.]] | [[Category: Park-Snyder, S.]] | ||
| - | [[Category: Pascoe, L | + | [[Category: Pascoe, L T.]] |
| - | [[Category: Weis, W | + | [[Category: Weis, W I.]] |
[[Category: plakin repeat]] | [[Category: plakin repeat]] | ||
| - | ''Page seeded by [http:// | + | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Feb 21 13:46:15 2008'' |
Revision as of 11:46, 21 February 2008
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Structures of two intermediate filament-binding fragments of desmoplakin reveal a unique repeat motif structure
Contents |
Overview
Desmosomes are intercellular junctions in which cadherin cell adhesion molecules are linked to the intermediate filament (IF) system. Desmoplakin is a member of the plakin family of IF-binding proteins. The C-terminal domain of desmoplakin (DPCT) mediates binding to IFs in desmosomes. The DPCT sequence contains three regions, termed A, B and C, consisting of 4.5 copies of a 38-amino acid repeat motif. We demonstrate that these regions form discrete subdomains that bind to IFs and report the crystal structures of domains B and C. In contrast to the elongated structures formed by other kinds of repeat motifs, the plakin repeats form a globular structure with a unique fold. A conserved basic groove found on the domain may represent an IF-binding site.
Disease
Known diseases associated with this structure: Arrhythmogenic right ventricular dysplasia 8 OMIM:[125647], Dilated cardiomyopathy with woolly hair and keratoderma OMIM:[125647], Epidermolysis bullosa, lethal acantholytic OMIM:[125647], Keratosis palmoplantaris striata II OMIM:[125647], Skin fragility-woolly hair syndrome OMIM:[125647]
About this Structure
1LM7 is a Single protein structure of sequence from Homo sapiens. Full crystallographic information is available from OCA.
Reference
Structures of two intermediate filament-binding fragments of desmoplakin reveal a unique repeat motif structure., Choi HJ, Park-Snyder S, Pascoe LT, Green KJ, Weis WI, Nat Struct Biol. 2002 Aug;9(8):612-20. PMID:12101406
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