1lo5
From Proteopedia
(New page: 200px<br /> <applet load="1lo5" size="450" color="white" frame="true" align="right" spinBox="true" caption="1lo5, resolution 3.20Å" /> '''Crystal structure o...) |
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| - | [[Image:1lo5.gif|left|200px]]<br /> | + | [[Image:1lo5.gif|left|200px]]<br /><applet load="1lo5" size="350" color="white" frame="true" align="right" spinBox="true" |
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caption="1lo5, resolution 3.20Å" /> | caption="1lo5, resolution 3.20Å" /> | ||
'''Crystal structure of the D227A variant of Staphylococcal enterotoxin A in complex with human MHC class II'''<br /> | '''Crystal structure of the D227A variant of Staphylococcal enterotoxin A in complex with human MHC class II'''<br /> | ||
==Overview== | ==Overview== | ||
| - | Although the biological properties of staphylococcal enterotoxin A (SEA) | + | Although the biological properties of staphylococcal enterotoxin A (SEA) have been well characterized, structural insights into the interaction between SEA and major histocompatibilty complex (MHC) class II have only been obtained by modeling. Here, the crystal structure of the D227A variant of SEA in complex with human MHC class II has been determined by X-ray crystallography. SEA(D227A) exclusively binds with its N-terminal domain to the alpha chain of HLA-DR1. The ability of one SEA molecule to crosslink two MHC molecules was modeled. It shows that this SEA molecule cannot interact with the T cell receptor (TCR) while a second SEA molecule interacts with MHC. Because of its relatively low toxicity, the D227A variant of SEA is used in tumor therapy. |
==About this Structure== | ==About this Structure== | ||
| - | 1LO5 is a [http://en.wikipedia.org/wiki/Protein_complex Protein complex] structure of sequences from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] and [http://en.wikipedia.org/wiki/Staphylococcus_aureus Staphylococcus aureus]. Full crystallographic information is available from [http:// | + | 1LO5 is a [http://en.wikipedia.org/wiki/Protein_complex Protein complex] structure of sequences from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] and [http://en.wikipedia.org/wiki/Staphylococcus_aureus Staphylococcus aureus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1LO5 OCA]. |
==Reference== | ==Reference== | ||
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[[Category: protein-protein complex]] | [[Category: protein-protein complex]] | ||
| - | ''Page seeded by [http:// | + | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Feb 21 13:46:43 2008'' |
Revision as of 11:46, 21 February 2008
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Crystal structure of the D227A variant of Staphylococcal enterotoxin A in complex with human MHC class II
Overview
Although the biological properties of staphylococcal enterotoxin A (SEA) have been well characterized, structural insights into the interaction between SEA and major histocompatibilty complex (MHC) class II have only been obtained by modeling. Here, the crystal structure of the D227A variant of SEA in complex with human MHC class II has been determined by X-ray crystallography. SEA(D227A) exclusively binds with its N-terminal domain to the alpha chain of HLA-DR1. The ability of one SEA molecule to crosslink two MHC molecules was modeled. It shows that this SEA molecule cannot interact with the T cell receptor (TCR) while a second SEA molecule interacts with MHC. Because of its relatively low toxicity, the D227A variant of SEA is used in tumor therapy.
About this Structure
1LO5 is a Protein complex structure of sequences from Homo sapiens and Staphylococcus aureus. Full crystallographic information is available from OCA.
Reference
Crystal structure of a SEA variant in complex with MHC class II reveals the ability of SEA to crosslink MHC molecules., Petersson K, Thunnissen M, Forsberg G, Walse B, Structure. 2002 Dec;10(12):1619-26. PMID:12467569
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