1lof

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(New page: 200px<br /><applet load="1lof" size="450" color="white" frame="true" align="right" spinBox="true" caption="1lof, resolution 2.3&Aring;" /> '''X-RAY STRUCTURE OF A ...)
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[[Image:1lof.jpg|left|200px]]<br /><applet load="1lof" size="350" color="white" frame="true" align="right" spinBox="true"
caption="1lof, resolution 2.3&Aring;" />
caption="1lof, resolution 2.3&Aring;" />
'''X-RAY STRUCTURE OF A BIANTENNARY OCTASACCHARIDE-LECTIN COMPLEX AT 2.3 ANGSTROMS RESOLUTION'''<br />
'''X-RAY STRUCTURE OF A BIANTENNARY OCTASACCHARIDE-LECTIN COMPLEX AT 2.3 ANGSTROMS RESOLUTION'''<br />
==Overview==
==Overview==
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The structure and flexibility of saccharides have a profound and specific, influence in several biological processes such as protein protection and, the maintenance of conformational integrity, and in recognition events, involving viruses, enzymes, and lectins. To establish the structural bases, of these phenomena, we describe herein the extensively refined 2.3-A, resolution x-ray structure of a biantennary octasaccharide of the, N-acetyllactosamine type, complexed to isolectin I from Lathyrus ochrus., The two octasaccharides are located in clefts at each end of the long axis, of the lectin. The conformations of both the lectin and the saccharide are, slightly modified upon binding. The complex is stabilized by numerous, hydrogen bonds, many of them involving water molecules. It is also, stabilized by van der Waals interactions, including some with aromatic, residues. A more general model of a possible lectin-glycoprotein, interaction is also proposed.
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The structure and flexibility of saccharides have a profound and specific influence in several biological processes such as protein protection and the maintenance of conformational integrity, and in recognition events involving viruses, enzymes, and lectins. To establish the structural bases of these phenomena, we describe herein the extensively refined 2.3-A resolution x-ray structure of a biantennary octasaccharide of the N-acetyllactosamine type, complexed to isolectin I from Lathyrus ochrus. The two octasaccharides are located in clefts at each end of the long axis of the lectin. The conformations of both the lectin and the saccharide are slightly modified upon binding. The complex is stabilized by numerous hydrogen bonds, many of them involving water molecules. It is also stabilized by van der Waals interactions, including some with aromatic residues. A more general model of a possible lectin-glycoprotein interaction is also proposed.
==About this Structure==
==About this Structure==
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1LOF is a [http://en.wikipedia.org/wiki/Protein_complex Protein complex] structure of sequences from [http://en.wikipedia.org/wiki/Lathyrus_ochrus Lathyrus ochrus] with GAL, CA and MN as [http://en.wikipedia.org/wiki/ligands ligands]. Full crystallographic information is available from [http://ispc.weizmann.ac.il/oca-bin/ocashort?id=1LOF OCA].
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1LOF is a [http://en.wikipedia.org/wiki/Protein_complex Protein complex] structure of sequences from [http://en.wikipedia.org/wiki/Lathyrus_ochrus Lathyrus ochrus] with <scene name='pdbligand=GAL:'>GAL</scene>, <scene name='pdbligand=CA:'>CA</scene> and <scene name='pdbligand=MN:'>MN</scene> as [http://en.wikipedia.org/wiki/ligands ligands]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1LOF OCA].
==Reference==
==Reference==
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[[Category: lectin]]
[[Category: lectin]]
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''Page seeded by [http://ispc.weizmann.ac.il/oca OCA ] on Tue Nov 20 20:43:20 2007''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Feb 21 13:46:50 2008''

Revision as of 11:46, 21 February 2008

Image:1lof.jpg

1lof, resolution 2.3Å

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X-RAY STRUCTURE OF A BIANTENNARY OCTASACCHARIDE-LECTIN COMPLEX AT 2.3 ANGSTROMS RESOLUTION

Overview

The structure and flexibility of saccharides have a profound and specific influence in several biological processes such as protein protection and the maintenance of conformational integrity, and in recognition events involving viruses, enzymes, and lectins. To establish the structural bases of these phenomena, we describe herein the extensively refined 2.3-A resolution x-ray structure of a biantennary octasaccharide of the N-acetyllactosamine type, complexed to isolectin I from Lathyrus ochrus. The two octasaccharides are located in clefts at each end of the long axis of the lectin. The conformations of both the lectin and the saccharide are slightly modified upon binding. The complex is stabilized by numerous hydrogen bonds, many of them involving water molecules. It is also stabilized by van der Waals interactions, including some with aromatic residues. A more general model of a possible lectin-glycoprotein interaction is also proposed.

About this Structure

1LOF is a Protein complex structure of sequences from Lathyrus ochrus with , and as ligands. Full crystallographic information is available from OCA.

Reference

X-ray structure of a biantennary octasaccharide-lectin complex refined at 2.3-A resolution., Bourne Y, Rouge P, Cambillau C, J Biol Chem. 1992 Jan 5;267(1):197-203. PMID:1730588

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