1w4v

From Proteopedia

Revision as of 12:34, 30 October 2007

STRUCTURE OF THE OXIDISED FORM OF HUMAN THIOREDOXIN 2

Overview

Mammalian thioredoxin 2 is a mitochondrial isoform of highly evolutionary, conserved thioredoxins. Thioredoxins are small ubiquitous, protein-disulfide oxidoreductases implicated in a large variety of, biological functions. In mammals, thioredoxin 2 is encoded by a nuclear, gene and is targeted to mitochondria by a N-terminal mitochondrial, presequence. Recently, mitochondrial thioredoxin 2 was shown to interact, with components of the mitochondrial respiratory chain and to play a role, in the control of mitochondrial membrane potential, regulating, mitochondrial apoptosis signaling pathway. Here we report the first, crystal structures of a mammalian mitochondrial thioredoxin 2. Crystal, forms of reduced and oxidized human thioredoxin 2 are described at 2.0 and, 1.8 A resolution. Though ... [(full description)]

About this Structure

1W4V is a [Single protein] structure of sequence from [Homo sapiens]. Structure known Active Site: TRX. Full crystallographic information is available from [OCA].

Reference

Crystal structures of oxidized and reduced forms of human mitochondrial thioredoxin 2., Smeets A, Evrard C, Landtmeters M, Marchand C, Knoops B, Declercq JP, Protein Sci. 2005 Oct;14(10):2610-21. PMID:16195549

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