1m11
From Proteopedia
(New page: 200px<br /> <applet load="1m11" size="450" color="white" frame="true" align="right" spinBox="true" caption="1m11, resolution 16.0Å" /> '''structural model of...) |
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| - | [[Image:1m11.gif|left|200px]]<br /> | + | [[Image:1m11.gif|left|200px]]<br /><applet load="1m11" size="350" color="white" frame="true" align="right" spinBox="true" |
| - | <applet load="1m11" size=" | + | |
caption="1m11, resolution 16.0Å" /> | caption="1m11, resolution 16.0Å" /> | ||
'''structural model of human decay-accelerating factor bound to echovirus 7 from cryo-electron microscopy'''<br /> | '''structural model of human decay-accelerating factor bound to echovirus 7 from cryo-electron microscopy'''<br /> | ||
==Overview== | ==Overview== | ||
| - | Echoviruses are enteroviruses that belong to Picornaviridae. Many | + | Echoviruses are enteroviruses that belong to Picornaviridae. Many echoviruses use decay-accelerating factor (DAF) as their cellular receptor. DAF is a glycosylphosphatidyl inositol-anchored complement regulatory protein found on most cell surfaces. It functions to protect cells from complement attack. The cryo-electron microscopy reconstructions of echovirus 7 complexed with DAF show that the DAF-binding regions are located close to the icosahedral twofold axes, in contrast to other enterovirus complexes where the viral canyon is the receptor binding site. This novel receptor binding position suggests that DAF is important for the attachment of viral particles to host cells, but probably not for initiating viral uncoating, as is the case with canyon-binding receptors. Thus, a different cell entry mechanism must be used for enteroviruses that bind DAF. |
==Disease== | ==Disease== | ||
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==About this Structure== | ==About this Structure== | ||
| - | 1M11 is a [http://en.wikipedia.org/wiki/Protein_complex Protein complex] structure of sequences from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] and [http://en.wikipedia.org/wiki/Human_echovirus_6 Human echovirus 6]. Full crystallographic information is available from [http:// | + | 1M11 is a [http://en.wikipedia.org/wiki/Protein_complex Protein complex] structure of sequences from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] and [http://en.wikipedia.org/wiki/Human_echovirus_6 Human echovirus 6]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1M11 OCA]. |
==Reference== | ==Reference== | ||
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[[Category: Human echovirus 6]] | [[Category: Human echovirus 6]] | ||
[[Category: Protein complex]] | [[Category: Protein complex]] | ||
| - | [[Category: Baker, T | + | [[Category: Baker, T S.]] |
| - | [[Category: Bator, C | + | [[Category: Bator, C M.]] |
| - | [[Category: Chipman, P | + | [[Category: Chipman, P R.]] |
[[Category: He, Y.]] | [[Category: He, Y.]] | ||
| - | [[Category: Kuhn, R | + | [[Category: Kuhn, R J.]] |
[[Category: Lin, F.]] | [[Category: Lin, F.]] | ||
| - | [[Category: Medof, M | + | [[Category: Medof, M E.]] |
| - | [[Category: Rossmann, M | + | [[Category: Rossmann, M G.]] |
[[Category: Shoham, M.]] | [[Category: Shoham, M.]] | ||
[[Category: decay-accelerating factor]] | [[Category: decay-accelerating factor]] | ||
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[[Category: scr]] | [[Category: scr]] | ||
| - | ''Page seeded by [http:// | + | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Feb 21 13:50:20 2008'' |
Revision as of 11:50, 21 February 2008
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structural model of human decay-accelerating factor bound to echovirus 7 from cryo-electron microscopy
Contents |
Overview
Echoviruses are enteroviruses that belong to Picornaviridae. Many echoviruses use decay-accelerating factor (DAF) as their cellular receptor. DAF is a glycosylphosphatidyl inositol-anchored complement regulatory protein found on most cell surfaces. It functions to protect cells from complement attack. The cryo-electron microscopy reconstructions of echovirus 7 complexed with DAF show that the DAF-binding regions are located close to the icosahedral twofold axes, in contrast to other enterovirus complexes where the viral canyon is the receptor binding site. This novel receptor binding position suggests that DAF is important for the attachment of viral particles to host cells, but probably not for initiating viral uncoating, as is the case with canyon-binding receptors. Thus, a different cell entry mechanism must be used for enteroviruses that bind DAF.
Disease
Known diseases associated with this structure: Blood group Cromer OMIM:[125240], Blood group, Knops system OMIM:[120620], CR1 deficiency OMIM:[120620], Malaria, severe, resistance to OMIM:[120620], SLE susceptibility OMIM:[120620]
About this Structure
1M11 is a Protein complex structure of sequences from Homo sapiens and Human echovirus 6. Full crystallographic information is available from OCA.
Reference
Structure of decay-accelerating factor bound to echovirus 7: a virus-receptor complex., He Y, Lin F, Chipman PR, Bator CM, Baker TS, Shoham M, Kuhn RJ, Medof ME, Rossmann MG, Proc Natl Acad Sci U S A. 2002 Aug 6;99(16):10325-9. Epub 2002 Jul 15. PMID:12119400
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