1m4r
From Proteopedia
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==Overview== | ==Overview== | ||
| - | Interleukin-22 (IL-10-related T cell-derived inducible | + | Interleukin-22 (IL-10-related T cell-derived inducible factor/IL-TIF/IL-22) is a novel cytokine belonging to the IL-10 family. Recombinant human IL-22 (hIL-22) was found to activate the signal transducers and activators of transcription factors 1 and 3 as well as acute phase reactants in several hepatoma cell lines, suggesting its involvement in the inflammatory response. The crystallographic structure of recombinant hIL-22 has been solved at 2.0 A resolution using the SIRAS method. Contrary to IL-10, the hIL-22 dimer does not present an interpenetration of the secondary-structure elements belonging to the two distinct polypeptide chains but results from interface interactions between monomers. Structural differences between these two cytokines, revealed by the crystallographic studies, clearly indicate that, while a homodimer of IL-10 is required for signaling, hIL-22 most probably interacts with its receptor as a monomer. |
==About this Structure== | ==About this Structure== | ||
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[[Category: Colau, D.]] | [[Category: Colau, D.]] | ||
[[Category: Dumoutier, L.]] | [[Category: Dumoutier, L.]] | ||
| - | [[Category: Nagem, R | + | [[Category: Nagem, R A.P.]] |
[[Category: Ogata, C.]] | [[Category: Ogata, C.]] | ||
[[Category: Polikarpov, I.]] | [[Category: Polikarpov, I.]] | ||
| - | [[Category: Renauld, J | + | [[Category: Renauld, J C.]] |
[[Category: crystal structure]] | [[Category: crystal structure]] | ||
[[Category: cytokines]] | [[Category: cytokines]] | ||
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[[Category: interleukin-22 (il-22)]] | [[Category: interleukin-22 (il-22)]] | ||
| - | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on | + | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Feb 21 13:51:30 2008'' |
Revision as of 11:51, 21 February 2008
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CRYSTAL STRUCTURE OF RECOMBINANT HUMAN INTERLEUKIN-22
Overview
Interleukin-22 (IL-10-related T cell-derived inducible factor/IL-TIF/IL-22) is a novel cytokine belonging to the IL-10 family. Recombinant human IL-22 (hIL-22) was found to activate the signal transducers and activators of transcription factors 1 and 3 as well as acute phase reactants in several hepatoma cell lines, suggesting its involvement in the inflammatory response. The crystallographic structure of recombinant hIL-22 has been solved at 2.0 A resolution using the SIRAS method. Contrary to IL-10, the hIL-22 dimer does not present an interpenetration of the secondary-structure elements belonging to the two distinct polypeptide chains but results from interface interactions between monomers. Structural differences between these two cytokines, revealed by the crystallographic studies, clearly indicate that, while a homodimer of IL-10 is required for signaling, hIL-22 most probably interacts with its receptor as a monomer.
About this Structure
1M4R is a Single protein structure of sequence from Homo sapiens. Full crystallographic information is available from OCA.
Reference
Crystal structure of recombinant human interleukin-22., Nagem RA, Colau D, Dumoutier L, Renauld JC, Ogata C, Polikarpov I, Structure. 2002 Aug;10(8):1051-62. PMID:12176383
Page seeded by OCA on Thu Feb 21 13:51:30 2008
