1m4v

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(New page: 200px<br /><applet load="1m4v" size="450" color="white" frame="true" align="right" spinBox="true" caption="1m4v, resolution 1.90&Aring;" /> '''Crystal structure of...)
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[[Image:1m4v.gif|left|200px]]<br /><applet load="1m4v" size="450" color="white" frame="true" align="right" spinBox="true"
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[[Image:1m4v.gif|left|200px]]<br /><applet load="1m4v" size="350" color="white" frame="true" align="right" spinBox="true"
caption="1m4v, resolution 1.90&Aring;" />
caption="1m4v, resolution 1.90&Aring;" />
'''Crystal structure of SET3, a superantigen-like protein from Staphylococcus aureus'''<br />
'''Crystal structure of SET3, a superantigen-like protein from Staphylococcus aureus'''<br />
==Overview==
==Overview==
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The staphylococcal enterotoxin-like toxins (SETs) are a family of proteins, encoded within the Staphylococcus aureus genome that were identified by, their similarity to the well described bacterial superantigens. The first, crystal structure of a member of the SET family, SET3, has been determined, to 1.9 A (R = 0.205, R(free) = 0.240) and reveals a fold characteristic of, the superantigen family but with significant differences. The SET proteins, are secreted at varying levels by staphylococcal isolates, and, seroconversion studies of normal individuals indicate that they are, strongly antigenic to humans. Recombinant SETs do not exhibit any of the, properties expected of superantigens such as major histocompatibility, complex class II binding or broad T-cell activation, suggesting they have, an entirely different function. The fact that the whole gene family is, clustered within the pathogenicity island SaIn2 of the S. aureus genome, suggests that they are involved in host/pathogen interactions.
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The staphylococcal enterotoxin-like toxins (SETs) are a family of proteins encoded within the Staphylococcus aureus genome that were identified by their similarity to the well described bacterial superantigens. The first crystal structure of a member of the SET family, SET3, has been determined to 1.9 A (R = 0.205, R(free) = 0.240) and reveals a fold characteristic of the superantigen family but with significant differences. The SET proteins are secreted at varying levels by staphylococcal isolates, and seroconversion studies of normal individuals indicate that they are strongly antigenic to humans. Recombinant SETs do not exhibit any of the properties expected of superantigens such as major histocompatibility complex class II binding or broad T-cell activation, suggesting they have an entirely different function. The fact that the whole gene family is clustered within the pathogenicity island SaIn2 of the S. aureus genome suggests that they are involved in host/pathogen interactions.
==About this Structure==
==About this Structure==
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1M4V is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Staphylococcus_aureus Staphylococcus aureus]. Full crystallographic information is available from [http://ispc.weizmann.ac.il/oca-bin/ocashort?id=1M4V OCA].
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1M4V is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Staphylococcus_aureus Staphylococcus aureus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1M4V OCA].
==Reference==
==Reference==
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[[Category: Single protein]]
[[Category: Single protein]]
[[Category: Staphylococcus aureus]]
[[Category: Staphylococcus aureus]]
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[[Category: Arcus, V.L.]]
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[[Category: Arcus, V L.]]
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[[Category: Baker, E.N.]]
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[[Category: Baker, E N.]]
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[[Category: Fraser, J.D.]]
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[[Category: Fraser, J D.]]
[[Category: Langley, R.]]
[[Category: Langley, R.]]
[[Category: Proft, T.]]
[[Category: Proft, T.]]
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[[Category: superantigen fold]]
[[Category: superantigen fold]]
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''Page seeded by [http://ispc.weizmann.ac.il/oca OCA ] on Sun Nov 25 03:45:51 2007''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Feb 21 13:51:32 2008''

Revision as of 11:51, 21 February 2008

Image:1m4v.gif

1m4v, resolution 1.90Å

Drag the structure with the mouse to rotate

Crystal structure of SET3, a superantigen-like protein from Staphylococcus aureus

Overview

The staphylococcal enterotoxin-like toxins (SETs) are a family of proteins encoded within the Staphylococcus aureus genome that were identified by their similarity to the well described bacterial superantigens. The first crystal structure of a member of the SET family, SET3, has been determined to 1.9 A (R = 0.205, R(free) = 0.240) and reveals a fold characteristic of the superantigen family but with significant differences. The SET proteins are secreted at varying levels by staphylococcal isolates, and seroconversion studies of normal individuals indicate that they are strongly antigenic to humans. Recombinant SETs do not exhibit any of the properties expected of superantigens such as major histocompatibility complex class II binding or broad T-cell activation, suggesting they have an entirely different function. The fact that the whole gene family is clustered within the pathogenicity island SaIn2 of the S. aureus genome suggests that they are involved in host/pathogen interactions.

About this Structure

1M4V is a Single protein structure of sequence from Staphylococcus aureus. Full crystallographic information is available from OCA.

Reference

The Three-dimensional structure of a superantigen-like protein, SET3, from a pathogenicity island of the Staphylococcus aureus genome., Arcus VL, Langley R, Proft T, Fraser JD, Baker EN, J Biol Chem. 2002 Aug 30;277(35):32274-81. Epub 2002 Jun 24. PMID:12082105

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