1m9o
From Proteopedia
(New page: 200px<br /><applet load="1m9o" size="450" color="white" frame="true" align="right" spinBox="true" caption="1m9o" /> '''NMR structure of the first Zinc Binding doma...) |
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| - | [[Image:1m9o.gif|left|200px]]<br /><applet load="1m9o" size=" | + | [[Image:1m9o.gif|left|200px]]<br /><applet load="1m9o" size="350" color="white" frame="true" align="right" spinBox="true" |
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'''NMR structure of the first Zinc Binding domain of Nup475/TTP/TIS11'''<br /> | '''NMR structure of the first Zinc Binding domain of Nup475/TTP/TIS11'''<br /> | ||
==Overview== | ==Overview== | ||
| - | Nup475 (also known as tristetraprolin and TIS11) includes two zinc-binding | + | Nup475 (also known as tristetraprolin and TIS11) includes two zinc-binding domains of the form Cys-X8-Cys-X5-Cys-X3-His. These domains are required for rapid degradation of tumor necrosis factor (TNF) and other mRNAs through the interaction with AU-rich elements in their 3'-untranslated regions. The three-dimensional solution structure of the first domain was determined by multidimensional nuclear magnetic resonance spectroscopy, revealing a novel fold around a central zinc ion. The core structure is disk-like with a diameter of approximately 25 A and a width of approximately 12 A. This structure provides a basis for evaluating the role of individual residues for structural stability and for nucleic acid binding. |
==About this Structure== | ==About this Structure== | ||
| - | 1M9O is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Mus_musculus Mus musculus] with ZN as [http://en.wikipedia.org/wiki/ligand ligand]. Full crystallographic information is available from [http:// | + | 1M9O is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Mus_musculus Mus musculus] with <scene name='pdbligand=ZN:'>ZN</scene> as [http://en.wikipedia.org/wiki/ligand ligand]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1M9O OCA]. |
==Reference== | ==Reference== | ||
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[[Category: Mus musculus]] | [[Category: Mus musculus]] | ||
[[Category: Single protein]] | [[Category: Single protein]] | ||
| - | [[Category: Amann, B | + | [[Category: Amann, B T.]] |
| - | [[Category: Berg, J | + | [[Category: Berg, J M.]] |
| - | [[Category: Worthington, M | + | [[Category: Worthington, M T.]] |
[[Category: ZN]] | [[Category: ZN]] | ||
[[Category: cys3his type zinc finger]] | [[Category: cys3his type zinc finger]] | ||
| - | ''Page seeded by [http:// | + | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Feb 21 13:52:57 2008'' |
Revision as of 11:53, 21 February 2008
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NMR structure of the first Zinc Binding domain of Nup475/TTP/TIS11
Overview
Nup475 (also known as tristetraprolin and TIS11) includes two zinc-binding domains of the form Cys-X8-Cys-X5-Cys-X3-His. These domains are required for rapid degradation of tumor necrosis factor (TNF) and other mRNAs through the interaction with AU-rich elements in their 3'-untranslated regions. The three-dimensional solution structure of the first domain was determined by multidimensional nuclear magnetic resonance spectroscopy, revealing a novel fold around a central zinc ion. The core structure is disk-like with a diameter of approximately 25 A and a width of approximately 12 A. This structure provides a basis for evaluating the role of individual residues for structural stability and for nucleic acid binding.
About this Structure
1M9O is a Single protein structure of sequence from Mus musculus with as ligand. Full crystallographic information is available from OCA.
Reference
A Cys3His zinc-binding domain from Nup475/tristetraprolin: a novel fold with a disklike structure., Amann BT, Worthington MT, Berg JM, Biochemistry. 2003 Jan 14;42(1):217-21. PMID:12515557
Page seeded by OCA on Thu Feb 21 13:52:57 2008
