1me4
From Proteopedia
(New page: 200px<br /><applet load="1me4" size="450" color="white" frame="true" align="right" spinBox="true" caption="1me4, resolution 1.2Å" /> '''High Resolution Cryst...) |
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| - | [[Image:1me4.jpg|left|200px]]<br /><applet load="1me4" size=" | + | [[Image:1me4.jpg|left|200px]]<br /><applet load="1me4" size="350" color="white" frame="true" align="right" spinBox="true" |
caption="1me4, resolution 1.2Å" /> | caption="1me4, resolution 1.2Å" /> | ||
'''High Resolution Crystal Structure Analysis Of Cruzain non-covalently Bound To A Hydroxymethyl Ketone Inhibitor (I)'''<br /> | '''High Resolution Crystal Structure Analysis Of Cruzain non-covalently Bound To A Hydroxymethyl Ketone Inhibitor (I)'''<br /> | ||
==Overview== | ==Overview== | ||
| - | The crystal structures of two hydroxymethyl ketone inhibitors complexed to | + | The crystal structures of two hydroxymethyl ketone inhibitors complexed to the cysteine protease cruzain have been determined at 1.1 and 1.2 A resolution, respectively. These high resolution crystal structures provide the first structures of non-covalent inhibitors bound to cruzain. A series of compounds were prepared and tested based upon the structures providing further insight into the key binding interactions. |
==About this Structure== | ==About this Structure== | ||
| - | 1ME4 is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Trypanosoma_cruzi Trypanosoma cruzi] with T10 as [http://en.wikipedia.org/wiki/ligand ligand]. Full crystallographic information is available from [http:// | + | 1ME4 is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Trypanosoma_cruzi Trypanosoma cruzi] with <scene name='pdbligand=T10:'>T10</scene> as [http://en.wikipedia.org/wiki/ligand ligand]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1ME4 OCA]. |
==Reference== | ==Reference== | ||
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[[Category: Single protein]] | [[Category: Single protein]] | ||
[[Category: Trypanosoma cruzi]] | [[Category: Trypanosoma cruzi]] | ||
| - | [[Category: Brinen, L | + | [[Category: Brinen, L S.]] |
| - | [[Category: Ellman, J | + | [[Category: Ellman, J A.]] |
[[Category: Huang, L.]] | [[Category: Huang, L.]] | ||
[[Category: T10]] | [[Category: T10]] | ||
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[[Category: non-covalent inhibitor]] | [[Category: non-covalent inhibitor]] | ||
| - | ''Page seeded by [http:// | + | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Feb 21 13:54:19 2008'' |
Revision as of 11:54, 21 February 2008
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High Resolution Crystal Structure Analysis Of Cruzain non-covalently Bound To A Hydroxymethyl Ketone Inhibitor (I)
Overview
The crystal structures of two hydroxymethyl ketone inhibitors complexed to the cysteine protease cruzain have been determined at 1.1 and 1.2 A resolution, respectively. These high resolution crystal structures provide the first structures of non-covalent inhibitors bound to cruzain. A series of compounds were prepared and tested based upon the structures providing further insight into the key binding interactions.
About this Structure
1ME4 is a Single protein structure of sequence from Trypanosoma cruzi with as ligand. Full crystallographic information is available from OCA.
Reference
Crystal structures of reversible ketone-Based inhibitors of the cysteine protease cruzain., Huang L, Brinen LS, Ellman JA, Bioorg Med Chem. 2003 Jan 2;11(1):21-9. PMID:12467703
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