1yrs

From Proteopedia

Revision as of 13:29, 20 October 2012

spinqualitylabelsall models PDB ID 1yrs Show:Asymmetric Unit Biological Assembly Drag the structure with the mouse to rotate   Export Animated Image
1yrs, resolution 2.50Å ()
Ligands:	, ,
Gene:	KIF11, EG5, KNSL1 (Homo sapiens)
Structural annotation: Resources: CATH : 1Yrsa00, 1Yrsb00 InterPro : Ipr001752 Pfam : PF00225 UniProt : P52732
Functional annotation: Cellular component: spindle microtubule kinesin complex microtubule spindle pole microtubule associated complex spindle Biological process: spindle pole body organization and biogenesis mitosis mitotic spindle organization and biogenesis mitotic centrosome separation microtubule-based movement cell division cell cycle Molecular function: motor activity nucleotide binding ATP binding microtubule motor activity
Evolutionary conservation: Toggle Conservation Colors: Rows = identical sequences: Further Information: Caveats, Explanation, Complete Results at ConSurfDB
Resources:	FirstGlance, OCA, RCSB, PDBsum
Coordinates:	save as pdb, mmCIF, xml

Crystal structure of KSP in complex with inhibitor 1

Template:ABSTRACT PUBMED 15808464

About this Structure

1yrs is a 2 chain structure with sequence from Homo sapiens. Full crystallographic information is available from OCA.

See Also

• Kinesin
• Kinesin-5

Reference

• Cox CD, Breslin MJ, Mariano BJ, Coleman PJ, Buser CA, Walsh ES, Hamilton K, Huber HE, Kohl NE, Torrent M, Yan Y, Kuo LC, Hartman GD. Kinesin spindle protein (KSP) inhibitors. Part 1: The discovery of 3,5-diaryl-4,5-dihydropyrazoles as potent and selective inhibitors of the mitotic kinesin KSP. Bioorg Med Chem Lett. 2005 Apr 15;15(8):2041-5. PMID:15808464 doi:10.1016/j.bmcl.2005.02.055