1mk7
From Proteopedia
(New page: 200px<br /> <applet load="1mk7" size="450" color="white" frame="true" align="right" spinBox="true" caption="1mk7, resolution 2.20Å" /> '''CRYSTAL STRUCTURE O...) |
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| - | [[Image:1mk7.gif|left|200px]]<br /> | + | [[Image:1mk7.gif|left|200px]]<br /><applet load="1mk7" size="350" color="white" frame="true" align="right" spinBox="true" |
| - | <applet load="1mk7" size=" | + | |
caption="1mk7, resolution 2.20Å" /> | caption="1mk7, resolution 2.20Å" /> | ||
'''CRYSTAL STRUCTURE OF AN INTEGRIN BETA3-TALIN CHIMERA'''<br /> | '''CRYSTAL STRUCTURE OF AN INTEGRIN BETA3-TALIN CHIMERA'''<br /> | ||
==Overview== | ==Overview== | ||
| - | The binding of cytoplasmic proteins, such as talin, to the cytoplasmic | + | The binding of cytoplasmic proteins, such as talin, to the cytoplasmic domains of integrin adhesion receptors mediates bidirectional signal transduction. Here we report the crystal structure of the principal integrin binding and activating fragment of talin, alone and in complex with fragments of the beta 3 integrin tail. The FERM (four point one, ezrin, radixin, and moesin) domain of talin engages integrins via a novel variant of the canonical phosphotyrosine binding (PTB) domain-NPxY ligand interaction that may be a prototype for FERM domain recognition of transmembrane receptors. In combination with NMR and mutational analysis, our studies reveal the critical interacting elements of both talin and the integrin beta 3 tail, providing structural paradigms for integrin linkage to the cell interior. |
==Disease== | ==Disease== | ||
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==About this Structure== | ==About this Structure== | ||
| - | 1MK7 is a [http://en.wikipedia.org/wiki/Protein_complex Protein complex] structure of sequences from [http://en.wikipedia.org/wiki/Gallus_gallus Gallus gallus] and [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http:// | + | 1MK7 is a [http://en.wikipedia.org/wiki/Protein_complex Protein complex] structure of sequences from [http://en.wikipedia.org/wiki/Gallus_gallus Gallus gallus] and [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1MK7 OCA]. |
==Reference== | ==Reference== | ||
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[[Category: Homo sapiens]] | [[Category: Homo sapiens]] | ||
[[Category: Protein complex]] | [[Category: Protein complex]] | ||
| - | [[Category: Calderwood, D | + | [[Category: Calderwood, D A.]] |
| - | [[Category: Campbell, I | + | [[Category: Campbell, I D.]] |
[[Category: Critchley, D.]] | [[Category: Critchley, D.]] | ||
[[Category: Garcia-Alvarez, B.]] | [[Category: Garcia-Alvarez, B.]] | ||
| - | [[Category: Ginsberg, M | + | [[Category: Ginsberg, M H.]] |
| - | [[Category: Liddington, R | + | [[Category: Liddington, R C.]] |
| - | [[Category: Pereda, J | + | [[Category: Pereda, J M.De.]] |
| - | [[Category: Ulmer, T | + | [[Category: Ulmer, T S.]] |
[[Category: cytoskeleton]] | [[Category: cytoskeleton]] | ||
[[Category: ferm domain]] | [[Category: ferm domain]] | ||
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[[Category: ptb domain]] | [[Category: ptb domain]] | ||
| - | ''Page seeded by [http:// | + | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Feb 21 13:55:58 2008'' |
Revision as of 11:56, 21 February 2008
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CRYSTAL STRUCTURE OF AN INTEGRIN BETA3-TALIN CHIMERA
Contents |
Overview
The binding of cytoplasmic proteins, such as talin, to the cytoplasmic domains of integrin adhesion receptors mediates bidirectional signal transduction. Here we report the crystal structure of the principal integrin binding and activating fragment of talin, alone and in complex with fragments of the beta 3 integrin tail. The FERM (four point one, ezrin, radixin, and moesin) domain of talin engages integrins via a novel variant of the canonical phosphotyrosine binding (PTB) domain-NPxY ligand interaction that may be a prototype for FERM domain recognition of transmembrane receptors. In combination with NMR and mutational analysis, our studies reveal the critical interacting elements of both talin and the integrin beta 3 tail, providing structural paradigms for integrin linkage to the cell interior.
Disease
Known diseases associated with this structure: Glanzmann thrombasthenia, type B OMIM:[173470]
About this Structure
1MK7 is a Protein complex structure of sequences from Gallus gallus and Homo sapiens. Full crystallographic information is available from OCA.
Reference
Structural determinants of integrin recognition by talin., Garcia-Alvarez B, de Pereda JM, Calderwood DA, Ulmer TS, Critchley D, Campbell ID, Ginsberg MH, Liddington RC, Mol Cell. 2003 Jan;11(1):49-58. PMID:12535520
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