1mk2
From Proteopedia
(New page: 200px<br /> <applet load="1mk2" size="450" color="white" frame="true" align="right" spinBox="true" caption="1mk2, resolution 2.74Å" /> '''SMAD3 SBD complex''...) |
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| - | [[Image:1mk2.gif|left|200px]]<br /> | + | [[Image:1mk2.gif|left|200px]]<br /><applet load="1mk2" size="350" color="white" frame="true" align="right" spinBox="true" |
| - | <applet load="1mk2" size=" | + | |
caption="1mk2, resolution 2.74Å" /> | caption="1mk2, resolution 2.74Å" /> | ||
'''SMAD3 SBD complex'''<br /> | '''SMAD3 SBD complex'''<br /> | ||
==Overview== | ==Overview== | ||
| - | Smad3 transduces the signals of TGF-betas, coupling transmembrane receptor | + | Smad3 transduces the signals of TGF-betas, coupling transmembrane receptor kinase activation to transcriptional control. The membrane-associated molecule SARA (Smad Anchor for Receptor Activation) recruits Smad3 for phosphorylation by the receptor kinase. Upon phosphorylation, Smad3 dissociates from SARA and enters the nucleus, in which its transcriptional activity can be repressed by Ski. Here, we show that SARA and Ski recognize specifically the monomeric and trimeric forms of Smad3, respectively. Thus, trimerization of Smad3, induced by phosphorylation, simultaneously activates the TGF-beta signal by driving Smad3 dissociation from SARA and sets up the negative feedback mechanism by Ski. Structural models of the Smad3/SARA/receptor kinase complex and Smad3/Ski complex provide insights into the molecular basis of regulation. |
==Disease== | ==Disease== | ||
| - | Known diseases associated with this structure: Anderson disease OMIM:[[http://www.ncbi.nlm.nih.gov/entrez/dispomim.cgi?id=607690 607690]], Chylomicron retention disease | + | Known diseases associated with this structure: Anderson disease OMIM:[[http://www.ncbi.nlm.nih.gov/entrez/dispomim.cgi?id=607690 607690]], Chylomicron retention disease OMIM:[[http://www.ncbi.nlm.nih.gov/entrez/dispomim.cgi?id=607690 607690]], Mowat-Wilson syndrome OMIM:[[http://www.ncbi.nlm.nih.gov/entrez/dispomim.cgi?id=605802 605802]] |
==About this Structure== | ==About this Structure== | ||
| - | 1MK2 is a [http://en.wikipedia.org/wiki/Protein_complex Protein complex] structure of sequences from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] with ACY as [http://en.wikipedia.org/wiki/ligand ligand]. Full crystallographic information is available from [http:// | + | 1MK2 is a [http://en.wikipedia.org/wiki/Protein_complex Protein complex] structure of sequences from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] with <scene name='pdbligand=ACY:'>ACY</scene> as [http://en.wikipedia.org/wiki/ligand ligand]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1MK2 OCA]. |
==Reference== | ==Reference== | ||
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[[Category: Homo sapiens]] | [[Category: Homo sapiens]] | ||
[[Category: Protein complex]] | [[Category: Protein complex]] | ||
| - | [[Category: Correia, J | + | [[Category: Correia, J J.]] |
| - | [[Category: Lam, S | + | [[Category: Lam, S S.]] |
[[Category: Lin, K.]] | [[Category: Lin, K.]] | ||
| - | [[Category: Qin, B | + | [[Category: Qin, B Y.]] |
[[Category: ACY]] | [[Category: ACY]] | ||
[[Category: sara]] | [[Category: sara]] | ||
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[[Category: smad3]] | [[Category: smad3]] | ||
| - | ''Page seeded by [http:// | + | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Feb 21 13:56:00 2008'' |
Revision as of 11:56, 21 February 2008
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SMAD3 SBD complex
Contents |
Overview
Smad3 transduces the signals of TGF-betas, coupling transmembrane receptor kinase activation to transcriptional control. The membrane-associated molecule SARA (Smad Anchor for Receptor Activation) recruits Smad3 for phosphorylation by the receptor kinase. Upon phosphorylation, Smad3 dissociates from SARA and enters the nucleus, in which its transcriptional activity can be repressed by Ski. Here, we show that SARA and Ski recognize specifically the monomeric and trimeric forms of Smad3, respectively. Thus, trimerization of Smad3, induced by phosphorylation, simultaneously activates the TGF-beta signal by driving Smad3 dissociation from SARA and sets up the negative feedback mechanism by Ski. Structural models of the Smad3/SARA/receptor kinase complex and Smad3/Ski complex provide insights into the molecular basis of regulation.
Disease
Known diseases associated with this structure: Anderson disease OMIM:[607690], Chylomicron retention disease OMIM:[607690], Mowat-Wilson syndrome OMIM:[605802]
About this Structure
1MK2 is a Protein complex structure of sequences from Homo sapiens with as ligand. Full crystallographic information is available from OCA.
Reference
Smad3 allostery links TGF-beta receptor kinase activation to transcriptional control., Qin BY, Lam SS, Correia JJ, Lin K, Genes Dev. 2002 Aug 1;16(15):1950-63. PMID:12154125
Page seeded by OCA on Thu Feb 21 13:56:00 2008
Categories: Homo sapiens | Protein complex | Correia, J J. | Lam, S S. | Lin, K. | Qin, B Y. | ACY | Sara | Sbd | Smad3
