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3qlg

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==About this Structure==
==About this Structure==
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[[3qlg]] is a 2 chain structure of [[C-Src tyrosine kinase]] with sequence from [http://en.wikipedia.org/wiki/Gallus_gallus Gallus gallus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3QLG OCA].
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[[3qlg]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Gallus_gallus Gallus gallus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3QLG OCA].
==See Also==
==See Also==

Revision as of 14:36, 20 October 2012

Image:3qlg.png

Template:STRUCTURE 3qlg

Contents

Crystal structure of the L317I mutant of the C-src tyrosine kinase domain complexed with dasatinib

Template:ABSTRACT PUBMED 17355866

About this Structure

3qlg is a 2 chain structure with sequence from Gallus gallus. Full crystallographic information is available from OCA.

See Also

Reference

  • Seeliger MA, Nagar B, Frank F, Cao X, Henderson MN, Kuriyan J. c-Src binds to the cancer drug imatinib with an inactive Abl/c-Kit conformation and a distributed thermodynamic penalty. Structure. 2007 Mar;15(3):299-311. PMID:17355866 doi:10.1016/j.str.2007.01.015
  • Dar AC, Lopez MS, Shokat KM. Small molecule recognition of c-Src via the Imatinib-binding conformation. Chem Biol. 2008 Oct 20;15(10):1015-22. PMID:18940662 doi:10.1016/j.chembiol.2008.09.007

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OCA

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