1mr1
From Proteopedia
(New page: 200px<br /> <applet load="1mr1" size="450" color="white" frame="true" align="right" spinBox="true" caption="1mr1, resolution 2.85Å" /> '''Crystal Structure o...) |
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| - | [[Image:1mr1.gif|left|200px]]<br /> | + | [[Image:1mr1.gif|left|200px]]<br /><applet load="1mr1" size="350" color="white" frame="true" align="right" spinBox="true" |
| - | <applet load="1mr1" size=" | + | |
caption="1mr1, resolution 2.85Å" /> | caption="1mr1, resolution 2.85Å" /> | ||
'''Crystal Structure of a Smad4-Ski Complex'''<br /> | '''Crystal Structure of a Smad4-Ski Complex'''<br /> | ||
==Overview== | ==Overview== | ||
| - | The Ski family of nuclear oncoproteins represses TGF-beta signaling | + | The Ski family of nuclear oncoproteins represses TGF-beta signaling through interactions with the Smad proteins. The crystal structure of the Smad4 binding domain of human c-Ski in complex with the MH2 domain of Smad4 reveals specific recognition of the Smad4 L3 loop region by a highly conserved interaction loop (I loop) from Ski. The Ski binding surface on Smad4 significantly overlaps with that required for binding of the R-Smads. Indeed, Ski disrupts the formation of a functional complex between the Co- and R-Smads, explaining how it could lead to repression of TGF-beta, activin, and BMP responses. Intriguingly, the structure of the Ski fragment, stabilized by a bound zinc atom, resembles the SAND domain, in which the corresponding I loop is responsible for DNA binding. |
==Disease== | ==Disease== | ||
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==About this Structure== | ==About this Structure== | ||
| - | 1MR1 is a [http://en.wikipedia.org/wiki/Protein_complex Protein complex] structure of sequences from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] with ZN as [http://en.wikipedia.org/wiki/ligand ligand]. Full crystallographic information is available from [http:// | + | 1MR1 is a [http://en.wikipedia.org/wiki/Protein_complex Protein complex] structure of sequences from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] with <scene name='pdbligand=ZN:'>ZN</scene> as [http://en.wikipedia.org/wiki/ligand ligand]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1MR1 OCA]. |
==Reference== | ==Reference== | ||
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[[Category: Protein complex]] | [[Category: Protein complex]] | ||
[[Category: Chai, J.]] | [[Category: Chai, J.]] | ||
| - | [[Category: Krawitz, A | + | [[Category: Krawitz, A R.]] |
[[Category: Li, W.]] | [[Category: Li, W.]] | ||
[[Category: Luo, K.]] | [[Category: Luo, K.]] | ||
[[Category: Shi, Y.]] | [[Category: Shi, Y.]] | ||
| - | [[Category: Wu, J | + | [[Category: Wu, J W.]] |
[[Category: Zhang, F.]] | [[Category: Zhang, F.]] | ||
[[Category: ZN]] | [[Category: ZN]] | ||
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[[Category: tgf-b signaling]] | [[Category: tgf-b signaling]] | ||
| - | ''Page seeded by [http:// | + | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Feb 21 13:58:12 2008'' |
Revision as of 11:58, 21 February 2008
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Crystal Structure of a Smad4-Ski Complex
Contents |
Overview
The Ski family of nuclear oncoproteins represses TGF-beta signaling through interactions with the Smad proteins. The crystal structure of the Smad4 binding domain of human c-Ski in complex with the MH2 domain of Smad4 reveals specific recognition of the Smad4 L3 loop region by a highly conserved interaction loop (I loop) from Ski. The Ski binding surface on Smad4 significantly overlaps with that required for binding of the R-Smads. Indeed, Ski disrupts the formation of a functional complex between the Co- and R-Smads, explaining how it could lead to repression of TGF-beta, activin, and BMP responses. Intriguingly, the structure of the Ski fragment, stabilized by a bound zinc atom, resembles the SAND domain, in which the corresponding I loop is responsible for DNA binding.
Disease
Known diseases associated with this structure: 1p36 deletion syndrome OMIM:[164780], Juvenile polyposis/hereditary hemorrhagic telangiectasia syndrome OMIM:[600993], Pancreatic cancer OMIM:[600993], Polyposis, juvenile intestinal OMIM:[600993]
About this Structure
1MR1 is a Protein complex structure of sequences from Homo sapiens with as ligand. Full crystallographic information is available from OCA.
Reference
Structural mechanism of Smad4 recognition by the nuclear oncoprotein Ski: insights on Ski-mediated repression of TGF-beta signaling., Wu JW, Krawitz AR, Chai J, Li W, Zhang F, Luo K, Shi Y, Cell. 2002 Nov 1;111(3):357-67. PMID:12419246
Page seeded by OCA on Thu Feb 21 13:58:12 2008
Categories: Homo sapiens | Protein complex | Chai, J. | Krawitz, A R. | Li, W. | Luo, K. | Shi, Y. | Wu, J W. | Zhang, F. | ZN | Cancer | Protein interaction | Ski | Smad | Tgf-b signaling
