1muj
From Proteopedia
(New page: 200px<br /><applet load="1muj" size="450" color="white" frame="true" align="right" spinBox="true" caption="1muj, resolution 2.15Å" /> '''Crystal structure of...) |
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| - | [[Image:1muj.gif|left|200px]]<br /><applet load="1muj" size=" | + | [[Image:1muj.gif|left|200px]]<br /><applet load="1muj" size="350" color="white" frame="true" align="right" spinBox="true" |
caption="1muj, resolution 2.15Å" /> | caption="1muj, resolution 2.15Å" /> | ||
'''Crystal structure of murine class II MHC I-Ab in complex with a human CLIP peptide'''<br /> | '''Crystal structure of murine class II MHC I-Ab in complex with a human CLIP peptide'''<br /> | ||
==Overview== | ==Overview== | ||
| - | Association between the class II major histocompatibility complex (MHC) | + | Association between the class II major histocompatibility complex (MHC) and the class II invariant chain-associated peptide (CLIP) occurs naturally as an intermediate step in the MHC class II processing pathway. Here, we report the crystal structure of the murine class II MHC molecule I-A(b) in complex with human CLIP at 2.15A resolution. The structure of I-A(b) accounts, via the peptide-binding groove's unique physicochemistry, for the distinct peptide repertoire bound by this allele. CLIP adopts a similar conformation to peptides bound by other I-A alleles, reinforcing the notion that CLIP is presented as a conventional peptide antigen. When compared to the related HLA-DR3/CLIP complex structure, the CLIP peptide displays a slightly different conformation and distinct interaction pattern with residues in I-A(b). In addition, after examining the published sequences of peptides presented by I-A(b), we discuss the possibility of predicting peptide alignment in the I-A(b) binding groove using a simple scoring matrix. |
==About this Structure== | ==About this Structure== | ||
| - | 1MUJ is a [http://en.wikipedia.org/wiki/Protein_complex Protein complex] structure of sequences from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] and [http://en.wikipedia.org/wiki/Mus_musculus Mus musculus] with NAG as [http://en.wikipedia.org/wiki/ligand ligand]. Full crystallographic information is available from [http:// | + | 1MUJ is a [http://en.wikipedia.org/wiki/Protein_complex Protein complex] structure of sequences from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] and [http://en.wikipedia.org/wiki/Mus_musculus Mus musculus] with <scene name='pdbligand=NAG:'>NAG</scene> as [http://en.wikipedia.org/wiki/ligand ligand]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1MUJ OCA]. |
==Reference== | ==Reference== | ||
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[[Category: Mus musculus]] | [[Category: Mus musculus]] | ||
[[Category: Protein complex]] | [[Category: Protein complex]] | ||
| - | [[Category: Wilson, I | + | [[Category: Wilson, I A.]] |
[[Category: Zhu, Y.]] | [[Category: Zhu, Y.]] | ||
[[Category: NAG]] | [[Category: NAG]] | ||
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[[Category: peptide]] | [[Category: peptide]] | ||
| - | ''Page seeded by [http:// | + | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Feb 21 13:59:10 2008'' |
Revision as of 11:59, 21 February 2008
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Crystal structure of murine class II MHC I-Ab in complex with a human CLIP peptide
Overview
Association between the class II major histocompatibility complex (MHC) and the class II invariant chain-associated peptide (CLIP) occurs naturally as an intermediate step in the MHC class II processing pathway. Here, we report the crystal structure of the murine class II MHC molecule I-A(b) in complex with human CLIP at 2.15A resolution. The structure of I-A(b) accounts, via the peptide-binding groove's unique physicochemistry, for the distinct peptide repertoire bound by this allele. CLIP adopts a similar conformation to peptides bound by other I-A alleles, reinforcing the notion that CLIP is presented as a conventional peptide antigen. When compared to the related HLA-DR3/CLIP complex structure, the CLIP peptide displays a slightly different conformation and distinct interaction pattern with residues in I-A(b). In addition, after examining the published sequences of peptides presented by I-A(b), we discuss the possibility of predicting peptide alignment in the I-A(b) binding groove using a simple scoring matrix.
About this Structure
1MUJ is a Protein complex structure of sequences from Homo sapiens and Mus musculus with as ligand. Full crystallographic information is available from OCA.
Reference
Crystal structure of MHC class II I-Ab in complex with a human CLIP peptide: prediction of an I-Ab peptide-binding motif., Zhu Y, Rudensky AY, Corper AL, Teyton L, Wilson IA, J Mol Biol. 2003 Feb 28;326(4):1157-74. PMID:12589760
Page seeded by OCA on Thu Feb 21 13:59:10 2008
Categories: Homo sapiens | Mus musculus | Protein complex | Wilson, I A. | Zhu, Y. | NAG | Antigen | Clip | Complex | Crystal structure | I-ab | Peptide
