1mup
From Proteopedia
(New page: 200px<br /><applet load="1mup" size="450" color="white" frame="true" align="right" spinBox="true" caption="1mup, resolution 2.4Å" /> '''PHEROMONE BINDING TO ...) |
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| - | [[Image:1mup.gif|left|200px]]<br /><applet load="1mup" size=" | + | [[Image:1mup.gif|left|200px]]<br /><applet load="1mup" size="350" color="white" frame="true" align="right" spinBox="true" |
caption="1mup, resolution 2.4Å" /> | caption="1mup, resolution 2.4Å" /> | ||
'''PHEROMONE BINDING TO TWO RODENT URINARY PROTEINS REVEALED BY X-RAY CRYSTALLOGRAPHY'''<br /> | '''PHEROMONE BINDING TO TWO RODENT URINARY PROTEINS REVEALED BY X-RAY CRYSTALLOGRAPHY'''<br /> | ||
==Overview== | ==Overview== | ||
| - | The principal protein excreted in male rat urine, urinary alpha 2-globulin | + | The principal protein excreted in male rat urine, urinary alpha 2-globulin and the homologous mouse protein, major urinary protein, have been well characterized, although their functions remain unclear. Male rat urine affects the behaviour and sexual response of female rats, leading to the proposal that rodent urinary proteins are responsible for binding pheromones and their subsequent release from drying urine. Urinary alpha 2-globulin is also involved in hyaline droplet nephropathy, an important toxicological syndrome in male rats resulting from exposure to a number of industrial chemicals and characterized by the accumulation of liganded urinary alpha 2-globulin in lysosomes in the kidney, followed by the induction of renal cancer. We now report the three-dimensional structures of mouse major urinary protein (at 2.4 A resolution) and rat urinary alpha 2-globulin (at 2.8 A resolution). The results corroborate the role of these proteins in pheromone transport and elaborate the structural basis of ligand binding. |
==About this Structure== | ==About this Structure== | ||
| - | 1MUP is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Mus_musculus Mus musculus] with CD and TZL as [http://en.wikipedia.org/wiki/ligands ligands]. Full crystallographic information is available from [http:// | + | 1MUP is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Mus_musculus Mus musculus] with <scene name='pdbligand=CD:'>CD</scene> and <scene name='pdbligand=TZL:'>TZL</scene> as [http://en.wikipedia.org/wiki/ligands ligands]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1MUP OCA]. |
==Reference== | ==Reference== | ||
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[[Category: Single protein]] | [[Category: Single protein]] | ||
[[Category: Bocskei, Z.]] | [[Category: Bocskei, Z.]] | ||
| - | [[Category: Flower, D | + | [[Category: Flower, D R.]] |
| - | [[Category: Groom, C | + | [[Category: Groom, C R.]] |
| - | [[Category: North, A | + | [[Category: North, A C.T.]] |
| - | [[Category: Phillips, S | + | [[Category: Phillips, S E.V.]] |
[[Category: CD]] | [[Category: CD]] | ||
[[Category: TZL]] | [[Category: TZL]] | ||
[[Category: pheromone-binding]] | [[Category: pheromone-binding]] | ||
| - | ''Page seeded by [http:// | + | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Feb 21 13:59:15 2008'' |
Revision as of 11:59, 21 February 2008
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PHEROMONE BINDING TO TWO RODENT URINARY PROTEINS REVEALED BY X-RAY CRYSTALLOGRAPHY
Overview
The principal protein excreted in male rat urine, urinary alpha 2-globulin and the homologous mouse protein, major urinary protein, have been well characterized, although their functions remain unclear. Male rat urine affects the behaviour and sexual response of female rats, leading to the proposal that rodent urinary proteins are responsible for binding pheromones and their subsequent release from drying urine. Urinary alpha 2-globulin is also involved in hyaline droplet nephropathy, an important toxicological syndrome in male rats resulting from exposure to a number of industrial chemicals and characterized by the accumulation of liganded urinary alpha 2-globulin in lysosomes in the kidney, followed by the induction of renal cancer. We now report the three-dimensional structures of mouse major urinary protein (at 2.4 A resolution) and rat urinary alpha 2-globulin (at 2.8 A resolution). The results corroborate the role of these proteins in pheromone transport and elaborate the structural basis of ligand binding.
About this Structure
1MUP is a Single protein structure of sequence from Mus musculus with and as ligands. Full crystallographic information is available from OCA.
Reference
Pheromone binding to two rodent urinary proteins revealed by X-ray crystallography., Bocskei Z, Groom CR, Flower DR, Wright CE, Phillips SE, Cavaggioni A, Findlay JB, North AC, Nature. 1992 Nov 12;360(6400):186-8. PMID:1279439
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