1db1
From Proteopedia
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{{STRUCTURE_1db1| PDB=1db1 | SCENE= }} | {{STRUCTURE_1db1| PDB=1db1 | SCENE= }} | ||
===CRYSTAL STRUCTURE OF THE NUCLEAR RECEPTOR FOR VITAMIN D COMPLEXED TO VITAMIN D=== | ===CRYSTAL STRUCTURE OF THE NUCLEAR RECEPTOR FOR VITAMIN D COMPLEXED TO VITAMIN D=== | ||
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{{ABSTRACT_PUBMED_10678179}} | {{ABSTRACT_PUBMED_10678179}} | ||
==About this Structure== | ==About this Structure== | ||
| - | + | [[1db1]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1DB1 OCA]. | |
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| + | ==See Also== | ||
| + | *[[Vitamin D receptor|Vitamin D receptor]] | ||
==Reference== | ==Reference== | ||
| - | <ref group="xtra">PMID: | + | <ref group="xtra">PMID:010678179</ref><ref group="xtra">PMID:011344298</ref><references group="xtra"/> |
[[Category: Homo sapiens]] | [[Category: Homo sapiens]] | ||
[[Category: Klaholz, B.]] | [[Category: Klaholz, B.]] | ||
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[[Category: Wurtz, J M.]] | [[Category: Wurtz, J M.]] | ||
[[Category: Complex]] | [[Category: Complex]] | ||
| - | + | [[Category: Gene regulation]] | |
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Revision as of 15:50, 20 October 2012
Contents |
CRYSTAL STRUCTURE OF THE NUCLEAR RECEPTOR FOR VITAMIN D COMPLEXED TO VITAMIN D
The action of 1 alpha, 25-dihydroxyvitamin D3 is mediated by its nuclear receptor (VDR), a ligand-dependent transcription regulator. We report the 1.8 A resolution crystal structure of the complex between a VDR ligand-binding domain (LBD) construct lacking the highly variable VDR-specific insertion domain and vitamin D. The construct exhibits the same binding affinity for vitamin D and transactivation ability as the wild-type protein, showing that the N-terminal part of the LBD is essential for its structural and functional integrity while the large insertion peptide is dispensable. The structure reveals the active conformation of the bound ligand and allows understanding of the different binding properties of some synthetic analogs.
The crystal structure of the nuclear receptor for vitamin D bound to its natural ligand., Rochel N, Wurtz JM, Mitschler A, Klaholz B, Moras D, Mol Cell. 2000 Jan;5(1):173-9. PMID:10678179
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.
About this Structure
1db1 is a 1 chain structure with sequence from Homo sapiens. Full crystallographic information is available from OCA.
See Also
Reference
- Rochel N, Wurtz JM, Mitschler A, Klaholz B, Moras D. The crystal structure of the nuclear receptor for vitamin D bound to its natural ligand. Mol Cell. 2000 Jan;5(1):173-9. PMID:10678179
- Tocchini-Valentini G, Rochel N, Wurtz JM, Mitschler A, Moras D. Crystal structures of the vitamin D receptor complexed to superagonist 20-epi ligands. Proc Natl Acad Sci U S A. 2001 May 8;98(10):5491-6. PMID:11344298 doi:10.1073/pnas.091018698
