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1a0k

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[[Category: profilin]]
[[Category: profilin]]
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''Page seeded by [http://ispc.weizmann.ac.il/oca OCA ] on Tue Oct 30 11:22:08 2007''
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''Page seeded by [http://ispc.weizmann.ac.il/oca OCA ] on Tue Oct 30 14:43:51 2007''

Revision as of 12:39, 30 October 2007


1a0k, resolution 2.2Å

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PROFILIN I FROM ARABIDOPSIS THALIANA

Overview

BACKGROUND: Profilins are small eukaryotic proteins involved in modulating, the assembly of actin microfilaments in the cytoplasm. They are able to, bind both phosphatidylinositol-4,5-bisphosphate and poly-L-proline (PLP), and thus play a critical role in signaling pathways. Plant profilins are, of interest because immunological cross-reactivity between pollen and, human profilin may be the cause of hay fever and broad allergies to, pollens. RESULTS: The determination of the Arabidopsis thaliana profilin, isoform I structure, using multiwavelength anomalous diffraction (MAD) to, obtain structure-factor phases, is reported here. The structure of, Arabidopsis profilin is similar to that of previously determined profilin, structures. Conserved amino acid residues in profilins from plants, ... [(full description)]

About this Structure

1A0K is a [Single protein] structure of sequence from [Arabidopsis thaliana]. Structure known Active Sites: AIN, GOL and PLY. Full crystallographic information is available from [OCA].

Reference

The crystal structure of a major allergen from plants., Thorn KS, Christensen HE, Shigeta R, Huddler D, Shalaby L, Lindberg U, Chua NH, Schutt CE, Structure. 1997 Jan 15;5(1):19-32. PMID:9016723

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