1n3n
From Proteopedia
(New page: 200px<br /><applet load="1n3n" size="450" color="white" frame="true" align="right" spinBox="true" caption="1n3n, resolution 3.0Å" /> '''Crystal structure of ...) |
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| - | [[Image:1n3n.gif|left|200px]]<br /><applet load="1n3n" size=" | + | [[Image:1n3n.gif|left|200px]]<br /><applet load="1n3n" size="350" color="white" frame="true" align="right" spinBox="true" |
caption="1n3n, resolution 3.0Å" /> | caption="1n3n, resolution 3.0Å" /> | ||
'''Crystal structure of a mycobacterial hsp60 epitope with the murine class I MHC molecule H-2Db'''<br /> | '''Crystal structure of a mycobacterial hsp60 epitope with the murine class I MHC molecule H-2Db'''<br /> | ||
==Overview== | ==Overview== | ||
| - | The decameric peptide SALQNAASIA from the Mycobacterium bovis heat shock | + | The decameric peptide SALQNAASIA from the Mycobacterium bovis heat shock protein (hsp) 60 is recognized by the murine T-cell receptor UZ-3-4 in complex with the murine class I major histocompatibility complex molecule H-2D(b). This T-cell receptor cross-reacts with the H-2D(b)-bound non-homologous decameric peptide KDIGNIISDA from the murine hsp60, but does not recognize the nonameric mycobacterial peptide SALQNAASI. Cross-recognition of the KDIGNIISDA/H-2D(b) complex induces autoimmune pathology in immunodeficient mice. We solved the X-ray crystal structure of the SALQNAASIA/H-2D(b) complex at 3.0 A resolution, and we modelled the KDIGNIISDA and SALQNAASI peptides in the H-2D(b) binding site. The structural analysis of the H-2D(b)-bound hsp60 epitopes offers insight into T-cell receptor cross-reactivity. |
==About this Structure== | ==About this Structure== | ||
| - | 1N3N is a [http://en.wikipedia.org/wiki/Protein_complex Protein complex] structure of sequences from [http://en.wikipedia.org/wiki/Mus_musculus Mus musculus] with SO4 as [http://en.wikipedia.org/wiki/ligand ligand]. Full crystallographic information is available from [http:// | + | 1N3N is a [http://en.wikipedia.org/wiki/Protein_complex Protein complex] structure of sequences from [http://en.wikipedia.org/wiki/Mus_musculus Mus musculus] with <scene name='pdbligand=SO4:'>SO4</scene> as [http://en.wikipedia.org/wiki/ligand ligand]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1N3N OCA]. |
==Reference== | ==Reference== | ||
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[[Category: Capitani, G.]] | [[Category: Capitani, G.]] | ||
[[Category: Ciatto, C.]] | [[Category: Ciatto, C.]] | ||
| - | [[Category: Grutter, M | + | [[Category: Grutter, M G.]] |
[[Category: Pecorari, F.]] | [[Category: Pecorari, F.]] | ||
[[Category: Pluckthun, A.]] | [[Category: Pluckthun, A.]] | ||
| - | [[Category: Tissot, A | + | [[Category: Tissot, A C.]] |
[[Category: SO4]] | [[Category: SO4]] | ||
[[Category: immunoglobulin fold]] | [[Category: immunoglobulin fold]] | ||
| - | ''Page seeded by [http:// | + | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Feb 21 14:01:53 2008'' |
Revision as of 12:01, 21 February 2008
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Crystal structure of a mycobacterial hsp60 epitope with the murine class I MHC molecule H-2Db
Overview
The decameric peptide SALQNAASIA from the Mycobacterium bovis heat shock protein (hsp) 60 is recognized by the murine T-cell receptor UZ-3-4 in complex with the murine class I major histocompatibility complex molecule H-2D(b). This T-cell receptor cross-reacts with the H-2D(b)-bound non-homologous decameric peptide KDIGNIISDA from the murine hsp60, but does not recognize the nonameric mycobacterial peptide SALQNAASI. Cross-recognition of the KDIGNIISDA/H-2D(b) complex induces autoimmune pathology in immunodeficient mice. We solved the X-ray crystal structure of the SALQNAASIA/H-2D(b) complex at 3.0 A resolution, and we modelled the KDIGNIISDA and SALQNAASI peptides in the H-2D(b) binding site. The structural analysis of the H-2D(b)-bound hsp60 epitopes offers insight into T-cell receptor cross-reactivity.
About this Structure
1N3N is a Protein complex structure of sequences from Mus musculus with as ligand. Full crystallographic information is available from OCA.
Reference
Structural analysis of mycobacterial and murine hsp60 epitopes in complex with the class I MHC molecule H-2Db., Ciatto C, Capitani G, Tissot AC, Pecorari F, Pluckthun A, Grutter MG, FEBS Lett. 2003 May 22;543(1-3):11-5. PMID:12753896
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