1ndy
From Proteopedia
(New page: 200px<br /><applet load="1ndy" size="450" color="white" frame="true" align="right" spinBox="true" caption="1ndy, resolution 2.Å" /> '''Crystal Structure of A...) |
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| - | [[Image:1ndy.jpg|left|200px]]<br /><applet load="1ndy" size=" | + | [[Image:1ndy.jpg|left|200px]]<br /><applet load="1ndy" size="350" color="white" frame="true" align="right" spinBox="true" |
caption="1ndy, resolution 2.Å" /> | caption="1ndy, resolution 2.Å" /> | ||
'''Crystal Structure of Adenosine Deaminase Complexed with FR230513'''<br /> | '''Crystal Structure of Adenosine Deaminase Complexed with FR230513'''<br /> | ||
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==About this Structure== | ==About this Structure== | ||
| - | 1NDY is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Bos_taurus Bos taurus] with ZN and FR3 as [http://en.wikipedia.org/wiki/ligands ligands]. Active as [http://en.wikipedia.org/wiki/Adenosine_deaminase Adenosine deaminase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.5.4.4 3.5.4.4] Full crystallographic information is available from [http:// | + | 1NDY is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Bos_taurus Bos taurus] with <scene name='pdbligand=ZN:'>ZN</scene> and <scene name='pdbligand=FR3:'>FR3</scene> as [http://en.wikipedia.org/wiki/ligands ligands]. Active as [http://en.wikipedia.org/wiki/Adenosine_deaminase Adenosine deaminase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.5.4.4 3.5.4.4] Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1NDY OCA]. |
==Reference== | ==Reference== | ||
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[[Category: tim-barrel]] | [[Category: tim-barrel]] | ||
| - | ''Page seeded by [http:// | + | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Feb 21 14:05:10 2008'' |
Revision as of 12:05, 21 February 2008
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Crystal Structure of Adenosine Deaminase Complexed with FR230513
Overview
We disclose herein the rapid discovery of the first highly potent (Ki = 7.7 nM) non-nucleoside adenosine deaminase (ADA) inhibitor based on the rational hybridization of two structurally distinct leads. Two micromolar inhibitors were discovered by a parallel rational design and random screening program, and individual crystal structures of bovine ADA in complexation with these inhibitors revealed several unknown binding sites and distinct binding modes. Using this information as the starting point, highly effective lead hybridization was achieved in only two structure-based drug design iterations. The conceptual approach illustrated by this example promises to be broadly useful in the search for new chemical entities and can contribute greatly to improve the overall efficiency and speed of drug discovery.
About this Structure
1NDY is a Single protein structure of sequence from Bos taurus with and as ligands. Active as Adenosine deaminase, with EC number 3.5.4.4 Full crystallographic information is available from OCA.
Reference
A highly potent non-nucleoside adenosine deaminase inhibitor: efficient drug discovery by intentional lead hybridization., Terasaka T, Kinoshita T, Kuno M, Nakanishi I, J Am Chem Soc. 2004 Jan 14;126(1):34-5. PMID:14709046
Page seeded by OCA on Thu Feb 21 14:05:10 2008
Categories: Adenosine deaminase | Bos taurus | Single protein | Kinoshita, T. | FR3 | ZN | Sbdd | Tim-barrel
