1nfk
From Proteopedia
(New page: 200px<br /><applet load="1nfk" size="450" color="white" frame="true" align="right" spinBox="true" caption="1nfk, resolution 2.300Å" /> '''STRUCTURE OF THE NU...) |
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| - | [[Image:1nfk.jpg|left|200px]]<br /><applet load="1nfk" size=" | + | [[Image:1nfk.jpg|left|200px]]<br /><applet load="1nfk" size="350" color="white" frame="true" align="right" spinBox="true" |
caption="1nfk, resolution 2.300Å" /> | caption="1nfk, resolution 2.300Å" /> | ||
'''STRUCTURE OF THE NUCLEAR FACTOR KAPPA-B (NF-KB) P50 HOMODIMER'''<br /> | '''STRUCTURE OF THE NUCLEAR FACTOR KAPPA-B (NF-KB) P50 HOMODIMER'''<br /> | ||
==Overview== | ==Overview== | ||
| - | The 2.3-A crystal structure of the transcription factor NK-kappa B p50 | + | The 2.3-A crystal structure of the transcription factor NK-kappa B p50 homodimer bound to a palindromic kappa B site reveals that the Rel homology region folds into two distinct domains, similar to those in the immunoglobulin superfamily. The p50 dimer envelopes an undistorted B-DNA helix, making specific contacts along the 10-base-pair kappa B recognition site mainly through loops connecting secondary structure elements in both domains. The carboxy-terminal domains form a dimerization interface between beta-sheets using residues that are strongly conserved in the Rel family. |
==About this Structure== | ==About this Structure== | ||
| - | 1NFK is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http:// | + | 1NFK is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1NFK OCA]. |
==Reference== | ==Reference== | ||
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[[Category: Mus musculus]] | [[Category: Mus musculus]] | ||
[[Category: Single protein]] | [[Category: Single protein]] | ||
| - | [[Category: Duyne, G | + | [[Category: Duyne, G Van.]] |
[[Category: Ghosh, G.]] | [[Category: Ghosh, G.]] | ||
[[Category: Ghosh, S.]] | [[Category: Ghosh, S.]] | ||
| - | [[Category: Sigler, P | + | [[Category: Sigler, P B.]] |
[[Category: complex (transcription factor/dna)]] | [[Category: complex (transcription factor/dna)]] | ||
[[Category: nf-kb p50]] | [[Category: nf-kb p50]] | ||
| - | ''Page seeded by [http:// | + | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Feb 21 14:05:34 2008'' |
Revision as of 12:05, 21 February 2008
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STRUCTURE OF THE NUCLEAR FACTOR KAPPA-B (NF-KB) P50 HOMODIMER
Overview
The 2.3-A crystal structure of the transcription factor NK-kappa B p50 homodimer bound to a palindromic kappa B site reveals that the Rel homology region folds into two distinct domains, similar to those in the immunoglobulin superfamily. The p50 dimer envelopes an undistorted B-DNA helix, making specific contacts along the 10-base-pair kappa B recognition site mainly through loops connecting secondary structure elements in both domains. The carboxy-terminal domains form a dimerization interface between beta-sheets using residues that are strongly conserved in the Rel family.
About this Structure
1NFK is a Single protein structure of sequence from Mus musculus. Full crystallographic information is available from OCA.
Reference
Structure of NF-kappa B p50 homodimer bound to a kappa B site., Ghosh G, van Duyne G, Ghosh S, Sigler PB, Nature. 1995 Jan 26;373(6512):303-10. PMID:7530332
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