1nhx
From Proteopedia
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==Overview== | ==Overview== | ||
| - | The analysis of the X-ray structures of two xanthine inhibitors bound to | + | The analysis of the X-ray structures of two xanthine inhibitors bound to PEPCK and a comparison to the X-ray structure of GTP bound to PEPCK are reported. The SAR at N-1, N-7 and developing SAR at C-8 are consistent with information gained from the X-ray structures of compounds 1 and 2 bound to PEPCK. Representative N-3 modifications of compound 2 that led to the discovery of 3-cyclopropylmethyl and its carboxy analogue as optimal N-3 groups are presented. |
==Disease== | ==Disease== | ||
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[[Category: Single protein]] | [[Category: Single protein]] | ||
[[Category: Dunten, P.]] | [[Category: Dunten, P.]] | ||
| - | [[Category: Foley, L | + | [[Category: Foley, L H.]] |
| - | [[Category: Gubler, M | + | [[Category: Gubler, M L.]] |
[[Category: Ramsey, G.]] | [[Category: Ramsey, G.]] | ||
[[Category: Wang, P.]] | [[Category: Wang, P.]] | ||
| - | [[Category: Wertheimer, S | + | [[Category: Wertheimer, S J.]] |
[[Category: EDO]] | [[Category: EDO]] | ||
[[Category: FTB]] | [[Category: FTB]] | ||
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[[Category: xanthine]] | [[Category: xanthine]] | ||
| - | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on | + | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Feb 21 14:06:22 2008'' |
Revision as of 12:06, 21 February 2008
|
PEPCK COMPLEX WITH A GTP-COMPETITIVE INHIBITOR
Contents |
Overview
The analysis of the X-ray structures of two xanthine inhibitors bound to PEPCK and a comparison to the X-ray structure of GTP bound to PEPCK are reported. The SAR at N-1, N-7 and developing SAR at C-8 are consistent with information gained from the X-ray structures of compounds 1 and 2 bound to PEPCK. Representative N-3 modifications of compound 2 that led to the discovery of 3-cyclopropylmethyl and its carboxy analogue as optimal N-3 groups are presented.
Disease
Known disease associated with this structure: Hypoglycemia due to PCK1 deficiency (1) OMIM:[261680]
About this Structure
1NHX is a Single protein structure of sequence from Homo sapiens with , , , and as ligands. Active as Phosphoenolpyruvate carboxykinase (GTP), with EC number 4.1.1.32 Full crystallographic information is available from OCA.
Reference
X-ray structures of two xanthine inhibitors bound to PEPCK and N-3 modifications of substituted 1,8-dibenzylxanthines., Foley LH, Wang P, Dunten P, Ramsey G, Gubler ML, Wertheimer SJ, Bioorg Med Chem Lett. 2003 Nov 3;13(21):3871-4. PMID:14552798
Page seeded by OCA on Thu Feb 21 14:06:22 2008
Categories: Homo sapiens | Phosphoenolpyruvate carboxykinase (GTP) | Single protein | Dunten, P. | Foley, L H. | Gubler, M L. | Ramsey, G. | Wang, P. | Wertheimer, S J. | EDO | FTB | MN | NA | PEP | Gluconeogenesis | Inhibitor | Xanthine
