1nik
From Proteopedia
(New page: 200px<br /><applet load="1nik" size="450" color="white" frame="true" align="right" spinBox="true" caption="1nik, resolution 4.10Å" /> '''Wild Type RNA Polyme...) |
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| - | [[Image:1nik.gif|left|200px]]<br /><applet load="1nik" size=" | + | [[Image:1nik.gif|left|200px]]<br /><applet load="1nik" size="350" color="white" frame="true" align="right" spinBox="true" |
caption="1nik, resolution 4.10Å" /> | caption="1nik, resolution 4.10Å" /> | ||
'''Wild Type RNA Polymerase II'''<br /> | '''Wild Type RNA Polymerase II'''<br /> | ||
==Overview== | ==Overview== | ||
| - | The x-ray structure of complete RNA polymerase II from Saccharomyces | + | The x-ray structure of complete RNA polymerase II from Saccharomyces cerevisiae has been determined, including a heterodimer of subunits Rpb4 and Rpb7 not present in previous "core" polymerase II structures. The heterodimer maintains the polymerase in the conformation of a transcribing complex, may bind RNA as it emerges from the enzyme, and is in a position to interact with general transcription factors and the Mediator of transcriptional regulation. |
==About this Structure== | ==About this Structure== | ||
| - | 1NIK is a [http://en.wikipedia.org/wiki/Protein_complex Protein complex] structure of sequences from [http://en.wikipedia.org/wiki/Saccharomyces_cerevisiae Saccharomyces cerevisiae] with ZN as [http://en.wikipedia.org/wiki/ligand ligand]. Active as [http://en.wikipedia.org/wiki/DNA-directed_RNA_polymerase DNA-directed RNA polymerase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.7.6 2.7.7.6] Full crystallographic information is available from [http:// | + | 1NIK is a [http://en.wikipedia.org/wiki/Protein_complex Protein complex] structure of sequences from [http://en.wikipedia.org/wiki/Saccharomyces_cerevisiae Saccharomyces cerevisiae] with <scene name='pdbligand=ZN:'>ZN</scene> as [http://en.wikipedia.org/wiki/ligand ligand]. Active as [http://en.wikipedia.org/wiki/DNA-directed_RNA_polymerase DNA-directed RNA polymerase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.7.6 2.7.7.6] Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1NIK OCA]. |
==Reference== | ==Reference== | ||
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[[Category: Protein complex]] | [[Category: Protein complex]] | ||
[[Category: Saccharomyces cerevisiae]] | [[Category: Saccharomyces cerevisiae]] | ||
| - | [[Category: Bushnell, D | + | [[Category: Bushnell, D A.]] |
| - | [[Category: Kornberg, R | + | [[Category: Kornberg, R D.]] |
[[Category: ZN]] | [[Category: ZN]] | ||
[[Category: transferase]] | [[Category: transferase]] | ||
| - | ''Page seeded by [http:// | + | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Feb 21 14:06:28 2008'' |
Revision as of 12:06, 21 February 2008
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Wild Type RNA Polymerase II
Overview
The x-ray structure of complete RNA polymerase II from Saccharomyces cerevisiae has been determined, including a heterodimer of subunits Rpb4 and Rpb7 not present in previous "core" polymerase II structures. The heterodimer maintains the polymerase in the conformation of a transcribing complex, may bind RNA as it emerges from the enzyme, and is in a position to interact with general transcription factors and the Mediator of transcriptional regulation.
About this Structure
1NIK is a Protein complex structure of sequences from Saccharomyces cerevisiae with as ligand. Active as DNA-directed RNA polymerase, with EC number 2.7.7.6 Full crystallographic information is available from OCA.
Reference
Complete, 12-subunit RNA polymerase II at 4.1-A resolution: implications for the initiation of transcription., Bushnell DA, Kornberg RD, Proc Natl Acad Sci U S A. 2003 Jun 10;100(12):6969-73. Epub 2003 May 13. PMID:12746498
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